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- 조회299
Nat. Commun., Jan 24 2025, 16 (1) 991 | https://doi.org/10.1038/s41467-025-56328-5
Liver-innervating vagal sensory neurons are indispensable for the development of hepatic steatosis and anxiety-like behavior in diet-induced obese mice
Jiyeon Hwang1,2, Sangbhin Lee1,2, Junichi Okada1,2, Li Liu1,2, Jeffrey E. Pessin1,2,3, Streamson C. Chua Jr1,2,4, Gary J. Schwartz1,2,4 & Young-Hwan Jo1,2,3,4
1The Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, New York, USA.
2Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, New York, USA.
3Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, USA.
4Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, USA.
Corresponding author
Correspondence to Young-Hwan Jo.
1The Fleischer Institute for Diabetes and Metabolism, Albert Einstein College of Medicine, New York, USA.
2Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, New York, USA.
3Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, USA.
4Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, USA.
Corresponding author
Correspondence to Young-Hwan Jo.
Abstract
The visceral organ-brain axis, mediated by vagal sensory neurons, is essential for maintaining various physiological functions. Here, we investigate the impact of liver-projecting vagal sensory neurons on energy balance, hepatic steatosis, and anxiety-like behavior in mice under obesogenic conditions. A small subset of vagal sensory neurons innervate the liver and project centrally to the nucleus of the tractus solitarius, area postrema, and dorsal motor nucleus of the vagus, and peripherally to the periportal areas in the liver. The loss of these neurons prevents diet-induced obesity, and these outcomes are associated with increased energy expenditure. Although males and females exhibit improved glucose homeostasis following disruption of liver-projecting vagal sensory neurons, only male mice display increased insulin sensitivity. Furthermore, the loss of liver-projecting vagal sensory neurons limits the progression of hepatic steatosis. Intriguingly, mice lacking liver-innervating vagal sensory neurons also exhibit less anxiety-like behavior compared to control mice. Modulation of the liver-brain axis may aid in designing effective treatments for both psychiatric and metabolic disorders associated with obesity and MAFLD.
논문정보
- Research article
- 2025년 01월 (BRIC 등록일 2025-01-27)
- 국외 연구진
- 의약학 > 신경의학
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