Thodhal Yoganandham Suman (전남대학교) | 한빛사논문 > 한빛사

한빛사논문

조회53

Thodhal Yoganandham SumanThodhal Yoganandham Suman

전남대학교

J. Hazard. Mater., Jan 16 2025, 487 S0304-3894(25)00161-X | https://doi.org/10.1016/j.jhazmat.2025.137249 Current understanding of human bioaccumulation patterns and health effects of exposure to perfluorooctane sulfonate (PFOS)

Thodhal Yoganandham Suman ^a, Ihn-Sil Kwak ^a,b

^aFisheries Science Institute, Chonnam National University, Yeosu 59626, South Korea
^bDepartment of Ocean Integrated Science, Chonnam National University, Yeosu 59626, South Korea

Correspondence to: Ihn-Sil Kwak

Abstract

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant of global concern due to its environmental presence,bioaccumulative potential and toxicological impacts. This review synthesizes current knowledge regarding PFOS exposure, bioaccumulation patterns and adverse health outcomes in human population. Analysis of worldwide biomonitoring data, and epidemiological studies reveals PFOS systemic effects, including immunological dysfunction (decreased vaccine response), developmental toxicity (reduced birth weight), hepatic metabolic disruption, potential carcinogenogenicity, and reproductive abnormalities. At the molecular level, PFOS induces toxicity through multiple pathways, including PI3K/AKT/mTOR pathway inhibition, PPARα activation, NF-κB signaling modulation, and oxidative stress induction. Recent advances in analytical methodologies have enhanced our understanding of PFOS distribution and fate, while evolving egulatory frameworks attempts to address its risk. This review identifies critical research gaps and emphasized the need for coordinated multidisciplinary approaches to address this persistent environmental contaminant.

논문정보

형식Review Paper
게재일2025년 01월 (BRIC 등록일 2025-02-07)
연구진국내 연구진
분야

댓글 작성 로그인

CV 열람하기

연락처 보기