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Adv. Sci., 22 January 2025 | https://doi.org/10.1002/advs.202412503 Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis

Dongkwan Shin ^{1 2 3}, Jeong-Ryeol Gong¹, Seoyoon D Jeong ¹, Youngwon Cho ⁴, Hwang-Phill Kim ⁴, Tae-You Kim ⁴, Kwang-Hyun Cho^{1 *}

¹Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
²Research Institute, National Cancer Center, Goyang, 10408, Republic of Korea.
³Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, 10408, Republic of Korea.
⁴Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 03080, Republic of Korea.

^*Corresponding author: correspondence to Kwang-Hyun Cho

Abstract

A cell fate change such as tumorigenesis incurs critical transition. It remains a longstanding challenge whether the underlying mechanism can be unraveled and a molecular switch that can reverse such transition is found. Here a systems framework, REVERT, is presented with which can reconstruct the core molecular regulatory network model and a reversion switch based on single-cell transcriptome data over the transition process is identified. The usefulness of REVERT is demonstrated by applying it to single-cell transcriptome of patient-derived matched organoids of colon cancer and normal colon. REVERT is a generic framework that can be applied to investigate various cell fate transition phenomena.

논문정보

형식Research article
게재일2025년 01월 (BRIC 등록일 2025-01-23)
연구진국내 연구진
분야 생명과학 > 생물공학

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