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J. Nanobiotechnol., Jan 18 2025, 23 (1) | https://doi.org/10.1186/s12951-024-03060-9 Therapeutic delivery of oxygen using artificial oxygen carriers demonstrates the possibility of treating a wide range of diseases

Nijaya Mohanto¹, Himangsu Mondal¹, Young‑Joon Park²and Jun‑Pil Jee^1,3*

¹College of Pharmacy, Chosun University, 309 Pilmun‑Daero, Dong‑Gu, Gwangju 61452, Republic of Korea.
²College of Pharmacy, Ajou University, Suwon, Gyeonggi, Republic of Korea.
³Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chosun University, Gwangju, Republic of Korea.

^*Correspondence: Jun‑Pil Jee

Abstract

Artificial oxygen carriers have emerged as potential substitutes for red blood cells in situations of major blood loss, including accidents, surgical procedures, trauma, childbirth, stomach ulcers, hemorrhagic shock, and blood vessel ruptures which can lead to sudden reduction in blood volume. The therapeutic delivery of oxygen utilizing artificial oxygen carriers as red blood cell substitutes presents a promising avenue for treating a spectrum of disease models. Apart from that, the recent advancement of artificial oxygen carriers intended to supplant conventional blood transfusions draws significant attention due to the exigencies of warfare and the ongoing challenges posed by the COVID-19 pandemic. However, there is a pressing need to formulate stable, non-toxic, and immunologically inert oxygen carriers. Even though numerous challenges are encountered in the development of artificial oxygen carriers, their applicability extends to various medical treatments, encompassing elective and cardiovascular surgeries, hemorrhagic shock, decompression illness, acute stroke, myocardial infarction, sickle cell crisis, and proficient addressing conditions such as cerebral hypoxia. Therefore, this paper provides an overview of therapeutic oxygen delivery using assorted types of artificial oxygen carriers, including hemoglobin-based, perfluorocarbon-based, stem cell-derived, and oxygen micro/nanobubbles, in the treatment of diverse disease models. Additionally, it discusses the potential side effects and limitations associated with these interventions, while incorporating completed and ongoing research and recent clinical developments. Finally, the prospective solutions and general demands of the perfect artificial oxygen carriers were anticipated to be a reference for subsequent research endeavors.

논문정보

형식Review Paper
게재일2025년 01월 (BRIC 등록일 2025-01-21)
연구진국내 연구진
분야 의약학 > 약학

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