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Mol. Psychiatr., https://doi.org/10.1038/s41380-024-02871-4
Effects of oxytocin administration on non-social executive functions in humans: a preregistered systematic review and meta-analysis
Heemin Kang 1, Bernt D. Glaser 1, Alina I. Sartorius 1, Kristin Audunsdottir 1,2, Emilie Smith-Meyer Kildal 2, Terje Nærland 2,3,4, Ole A. Andreassen 2,4, Lars T. Westlye 1,2 and Daniel S. Quintana 1,2,3,*
1Department of Psychology, University of Oslo, Oslo, Norway.
2K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
3NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway.
4Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital,
Oslo, Norway.
2K.G. Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
3NevSom, Department of Rare Disorders, Oslo University Hospital, Oslo, Norway.
4Centre for Precision Psychiatry, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital,
Oslo, Norway.
*Corresponding author: correspondence to Daniel S. Quintana
Abstract
Background
Oxytocin has received considerable research attention for its role in affiliative behaviors, particularly regarding its pro-social effects. More recent evidence has pointed to a broader role of oxytocin signaling, which includes non-social cognitive processes. However, meta-analytic data on oxytocin’s effects on non-social cognition is currently limited.
Methods
We registered plans for a systematic review and meta-analysis on the effects of oxytocin administration on non-social executive functions prior to data collection via a time-stamped protocol. We performed searches in PubMed, Europe PubMed Central, and the Bielefeld Academic Search Engine. We conducted a meta-analysis of 20 effect estimates from 13 eligible studies. Subgroup meta-analyses and a test for publication bias were also performed.
Results
We found no overall significant effect of oxytocin administration on non-social executive functions (p = 0.30; Hedges’ g = 0.07). However, effect sizes across sub-categories of executive function varied, where the effect of oxytocin administration was the largest for cognitive flexibility (p = 0.02; Hedges’ g = 0.2). Publication bias was assessed using Robust Bayesian Meta-Analysis, which yielded moderate support for the absence of publication bias (BFPB = 0.32).
Conclusion
Our analysis suggests that oxytocin’s effects may extend beyond social cognitive processing as data synthesis provided evidence supporting a role in non-social cognitive flexibility. The data and analysis output from this meta-analysis can be viewed in a point-and-click web application.
Oxytocin has received considerable research attention for its role in affiliative behaviors, particularly regarding its pro-social effects. More recent evidence has pointed to a broader role of oxytocin signaling, which includes non-social cognitive processes. However, meta-analytic data on oxytocin’s effects on non-social cognition is currently limited.
Methods
We registered plans for a systematic review and meta-analysis on the effects of oxytocin administration on non-social executive functions prior to data collection via a time-stamped protocol. We performed searches in PubMed, Europe PubMed Central, and the Bielefeld Academic Search Engine. We conducted a meta-analysis of 20 effect estimates from 13 eligible studies. Subgroup meta-analyses and a test for publication bias were also performed.
Results
We found no overall significant effect of oxytocin administration on non-social executive functions (p = 0.30; Hedges’ g = 0.07). However, effect sizes across sub-categories of executive function varied, where the effect of oxytocin administration was the largest for cognitive flexibility (p = 0.02; Hedges’ g = 0.2). Publication bias was assessed using Robust Bayesian Meta-Analysis, which yielded moderate support for the absence of publication bias (BFPB = 0.32).
Conclusion
Our analysis suggests that oxytocin’s effects may extend beyond social cognitive processing as data synthesis provided evidence supporting a role in non-social cognitive flexibility. The data and analysis output from this meta-analysis can be viewed in a point-and-click web application.
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- 2025년 01월 (BRIC 등록일 2025-01-24)
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