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Biomaterials, Available online 10 January 2025, 123103 | https://doi.org/10.1016/j.biomaterials.2025.123103
Conductive hydrogel luminal filler for peripheral nerve regeneration
Junggeon Park a †, Junghyun Kim a †, Goeun Choe b, Youngmee Jung b,c, Jae Young Lee a
aSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
bCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea
cSchool of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea
Corresponding author: Jae Young Lee
aSchool of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea
bCenter for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea
cSchool of Electrical and Electronic Engineering, YU-KIST Institute, Yonsei University, Seoul 03722, Republic of Korea
Corresponding author: Jae Young Lee
Abstract
Peripheral nerve injuries impair quality of life due to pain and loss of sensory and motor functions. Current treatments like autografts and nerve guidance conduits (NGCs) have limitations in functional restoration. Luminal fillers can enhance the effectiveness of NGCs by providing beneficial intraneural environments. In this study, we devised a novel injectable conductive luminal filler that allows for electrically active environments and efficient electrical stimulation of nerves. We developed injectable conductive hydrogel as a luminal filler for NGCs, composed of pluronic-coated reduced graphene oxide (rGO) and gelatin-based polymers, that gels spontaneously under physiological conditions. This filler combines nerve-like softness (0.31 ± 0.02 kPa), appropriate conductivity (2.7 ± 0.3 mS/cm), quick gelation (< 5 min), and in vivo degradability. In a rat peripheral nerve defect model, the conductive hydrogel filler with electrical stimulation showed promising results in nerve regrowth, myelination, and functional recovery, performing comparably to autografts. This study underscores the potential of conductive fillers in enhancing nerve regeneration therapies.
논문정보
- Research article
- 2025년 01월 (BRIC 등록일 2025-01-22)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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