한빛사
>
한빛사논문
한빛사논문
- 조회259
J. Control. Release, Dec 30 2024, 378 S0168-3659(24)00901-5 | https://doi.org/10.1016/j.jconrel.2024.12.046
Engineering the physical characteristics of biomaterials for innate immune-mediated cancer immunotherapy
Eun-Hye Kim a,b, Katelyn Wahl a,b, Erica Guelfi a,b, DaeYong Lee a,b
aFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA
bDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA
Corresponding author : DaeYong Lee
aFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA
bDepartment of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, USA
Corresponding author : DaeYong Lee
Abstract
It has recently been recognized that the physical characteristics of biomaterials - such as size, structure, shape, charge, mechanical strength, hydrophobicity, and multivalency - regulate immunological functions in innate immune cells. In immuno-oncology applications, biomaterials are engineered with distinct physical properties to achieve desired innate immune responses. In this review, we discuss how physical characteristics influence effector functions and innate immune signaling pathways in distinct innate immune cell subtypes. We highlight how physical properties of biomaterials impact phagocytosis regulation, biodistribution, and innate immune cell targeting. We outline the recent advances in physical engineering of biomaterials that directly or indirectly induce desired innate immune responses for cancer immunotherapy. Lastly, we discuss the challenges in current biomaterial approaches that need to be addressed to improve clinical applicability.
논문정보
- Research article
- 2024년 12월 (BRIC 등록일 2025-01-09)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
댓글 작성 로그인
팝업 닫기관련 링크
관련분야 연구자보기
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
