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Adv. Funct. Mater., 05 January 2025 | https://doi.org/10.1002/adfm.202417727
Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response-Enhanced Contact
Jeonghwa Jeong1, Gyeonghwa Heo1, Young Woo Kwon2, Seon Yeong Chae2, Min Jae Kim3, Ki Jun Yu4,5,6, Hwa Kyoung Shin3, Suck Won Hong1,2
1Department of Optics and Mechatronics Engineering, Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241 Republic of Korea
2Engineering Research Center for Color-Modulated Extra-Sensory Perception Technology, Pusan National University, Busan, 46241 Republic of Korea
3Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, 50612 Republic of Korea
4Department of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722 Republic of Korea
5YU-Korea Institute of Science and Technology (KIST) Institute, Seoul, 03722 Republic of Korea
6The Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673 Republic of Korea
J.J., G.H., Y.W.K., S.Y.C., and M.J.K. contributed equally to this work.
Corresponding Authors: Hwa Kyoung Shin, Suck Won Hong
1Department of Optics and Mechatronics Engineering, Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, 46241 Republic of Korea
2Engineering Research Center for Color-Modulated Extra-Sensory Perception Technology, Pusan National University, Busan, 46241 Republic of Korea
3Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, 50612 Republic of Korea
4Department of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722 Republic of Korea
5YU-Korea Institute of Science and Technology (KIST) Institute, Seoul, 03722 Republic of Korea
6The Biotech Center, Pohang University of Science and Technology (POSTECH), Pohang, 37673 Republic of Korea
J.J., G.H., Y.W.K., S.Y.C., and M.J.K. contributed equally to this work.
Corresponding Authors: Hwa Kyoung Shin, Suck Won Hong
Abstract
The ability to measure changes in neural activities using devices implanted in the brain can be useful for recording brain signals to assess specific risk factors, monitor the development of brain diseases, and expand the understanding of neural circuitry. Here, a neuroimplantable interface is introduced that integrates biomaterials with an advanced structural design to facilitate monitoring of electrophysiological responses in widespread brain regions. The neural interface uses biocompatible and photopatternable materials to create ultrathin, homogeneous encapsulant/substrate laminates. Comprehensive in vitro tests of the laminin-enveloped neural interface demonstrate efficacy in relieving inflammation via a biomimetic strategy by diminishing microglia and astrocyte aggregation near recording sites, enhancing periodic signal acquisition. The performance is evaluated by injecting an acetylcholine receptor agonist into mouse brains. This approach enables to monitor real-time signal changes, gain insights into neural network dynamics by assessing stimulus-evoked signaling at specific sites, and identify signaling patterns and hippocampal synaptic connections. Additionally, in a Parkinson's disease mouse model, deep brain stimulation is performed and signals are recorded to confirm symptom amelioration, offering a biomedical device approach. The key strategy highlights intact neural electrodes with biocompatible, mechanically compliant materials conferring compact bioelectronic functionalities, high neuronal microenvironment compatibility, and pathological neural system recognition.
논문정보
- Research article
- 2025년 01월 (BRIC 등록일 2025-01-07)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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