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유현재Hyunjae Yoo
서울대학교
Adv. Mater., Dec 24 2024, | https://doi.org/10.1002/adma.202412377
Ionic Diode-Based Drug Delivery System
Hyunjae Yoo 1, Soon-Bo Kang 1, Jeongsoo Kim 2, Wonkyung Cho 3, Hyojeong Ha 2, Seyoung Oh 2, Seol-Ha Jeong 4, Sihwan Lee 1, Hyemin Lee 2, Chang Seo Park 1, Dong-Yup Lee 1, Taek Dong Chung 3, Kyung-Mi Lee 2, Jeong-Yun Sun 1,5
1Department of Material Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
2Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
3Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea.
4School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
5Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, 08826, Republic of Korea.
H.Y., S.-B.K., and J.K. contributed equally to this work.
Corresponding Authors: Taek Dong Chung, Kyung-Mi Lee, Jeong-Yun Sun
1Department of Material Science and Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
2Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 02841, Republic of Korea.
3Department of Chemistry, Seoul National University, Seoul, 08826, Republic of Korea.
4School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea.
5Research Institute of Advanced Materials (RIAM), Seoul National University, Seoul, 08826, Republic of Korea.
H.Y., S.-B.K., and J.K. contributed equally to this work.
Corresponding Authors: Taek Dong Chung, Kyung-Mi Lee, Jeong-Yun Sun
Abstract
Drug delivery systems hold promise for delivering cytotoxic drugs by controlling the timing and location of the drug release. However, conventional delivery mechanisms often fall short of achieving spatiotemporally controlled yet sustained release, which is crucial for ensuring drug efficacy and minimizing impact on surrounding tissues. Here, an ionic diode-based drug delivery system is reported that is controlled by an electric potential and capable of releasing drugs at scales ranging from nanogram to microgram. The migrated drug is slowly but continuously diffused to the lesion through the hydrogel at the desired rate. The ionic diode provides flow-free drug delivery while minimizing unintended drug leakage over prolonged periods. Implanted in a freely moving tumor-bearing mouse model, the system filled with doxorubicin demonstrated superior anti-tumor efficacy and minimal off-target immune toxicity compared to the intratumoral injection of free doxorubicin. With its mechanically compliant and biocompatible components, the system offers a safe and readily translatable approach to patients with surgically unresectable tumors.
논문정보
- Research article
- 2024년 12월 (BRIC 등록일 2024-12-31)
- 국내 연구진
- 의약학 > 면역의학
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