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Adv. Funct. Mater., Volume33, Issue17, April 25, 2023 | https://doi.org/10.1002/adfm.202212325
Faster and Protective Wound Healing Mechanistic of Para-Coumaric Acid Loaded Liver ECM Scaffold Cross-linked with Acellular Marine Kelp
Asuva Arin1, Md Sohanur Rahaman1, Ume Farwa2, Byong-Taek Lee1,2*
1Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, 31151 Republic of Korea
2Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, 31151 Republic of Korea
A.A. and M.S.R. contributed equally to this work.
*Corresponding Author: Byong-Taek Lee
1Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, 31151 Republic of Korea
2Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, 31151 Republic of Korea
A.A. and M.S.R. contributed equally to this work.
*Corresponding Author: Byong-Taek Lee
Abstract
Decellularized liver-derived extracellular matrix is a unique combination of a complex milieu of growth factors and proteins that stimulate biochemical, physical, and mechanical cues to the cells. However, the lack of mechanical strength hindering the applicability of extracellular matrix (ECM) is an outstanding challenge. Herein, to deal with this problem, decellularized kelp is introduced as a crosslinking material thereby strengthening the physical structure of ECM for its utilization as a wound-healing material. Consequently, a significant architectural change is observed in the ECM by forming a solid-shaped scaffold. Nevertheless, the hindrance of high pH is addressed by incorporating the acidic drug p-coumaric acid. To evaluate the innate regenerative abilities, the scaffolds are applied to rat excisional wounds. A remarkable wound healing capability is demonstrated by both the EK scaffolds, but a faster regeneration is achieved with only EK-20@cou. The speculated hypothesis is that the incorporation of p-coumaric acid can offer many additional bioactive benefits to the scaffold such as remarkable biocompatibility, antioxidant, and anti-bacterial properties that are deliberately supported by the in vitro results. In silico molecular simulations (MS) validated that p-Cou released from the EK-20@Cou scaffold is accountable for the observed extraordinary regenerative behavior as compared to EK-20(PW).
논문정보
- Research article
- 2023년 04월 (BRIC 등록일 2024-12-19)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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