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Bioact. Mater., Available online 30 November 2024 | https://doi.org/10.1016/j.bioactmat.2024.11.020
Reduction reactions dominate the interactions between Mg alloys and cells: Understanding the mechanisms
Jua Kim a,b, Jeremy L. Gilbert b,c, William W. Lv d, Ping Du a, Haobo Pan a,e,f
aShenzhen Key Laboratory of Marine Biomaterials, CAS-HK Joint Lab of Biomaterials, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055, PR China
bSyracuse Biomaterials Institute, Syracuse University, 318 Bowne Hall, Syracuse University, Syracuse, NY, 13244, USA
cClemson- Medical University of South Carolina Bioengineering Program, Department of Bioengineering, Clemson University, 68 Presidents St, Charleston, SC, 39425, USA
dDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, PR China
eShenzhen Healthemes Biotechnology Co. Ltd, Shenzhen, 518102, PR China
fCollege of Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, PR China
Corresponding authors: Ping Du, Haobo Pan
aShenzhen Key Laboratory of Marine Biomaterials, CAS-HK Joint Lab of Biomaterials, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, 518055, PR China
bSyracuse Biomaterials Institute, Syracuse University, 318 Bowne Hall, Syracuse University, Syracuse, NY, 13244, USA
cClemson- Medical University of South Carolina Bioengineering Program, Department of Bioengineering, Clemson University, 68 Presidents St, Charleston, SC, 39425, USA
dDepartment of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, PR China
eShenzhen Healthemes Biotechnology Co. Ltd, Shenzhen, 518102, PR China
fCollege of Chemical Engineering, Xinjiang Normal University, Urumqi, 830054, PR China
Corresponding authors: Ping Du, Haobo Pan
Abstract
Magnesium (Mg) alloys are popular biodegradable metals studied for orthopedic and cardiovascular applications, mainly because Mg ions are essential trace elements known to promote angiogenesis and osteogenesis. However, Mg corrosion consists of oxidation and reduction reactions that produce by-products, such as hydrogen gas, reactive oxygen species, and hydroxides. It is still unclear how all these by-products and Mg ions concomitantly alter the microenvironment and cell behaviors spatially and temporally. This study shows that Mg corrosion can enhance cell proliferation by reducing intracellular ROS. However, Mg cannot decrease ROS and promote cell proliferation in simulated inflammatory conditions, meaning the microenvironment is critical. Furthermore, cells may respond to Mg ions differently in chronic or acute alkaline pH or oxidative stress. Depending on the corrosion rate, Mg modulates HIF1α and many signaling pathways like PI3K/AKT/mTOR, mitophagy, cell cycle, and oxidative phosphorylation. Therefore, this study provides a fundamental insight into the importance of reduction reactions in Mg alloys.
논문정보
- Research article
- 2025년 03월 (BRIC 등록일 2024-12-19)
- 국외 연구진
- 바이오·의료융합 > 바이오소재
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