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Nano Converg., Dec 11 2024, 11 (1) | https://doi.org/10.1186/s40580-024-00462-1
Nano-fluorescence imaging: advancing lymphatic disease diagnosis and monitoring
Chae Yeon Han1, Sang-Hun Choi1, Soo-Hyang Chi1, Ji Hyun Hong2, Young-Eun Cho3 and Jihoon Kim1*
1School of Integrative Engineering, Chung-Ang University, Seoul 06974, South Korea
2Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea
3Department of Food and Nutrition, Andong National University, Andong 36729, South Korea
*Correspondence: Jihoon Kim
1School of Integrative Engineering, Chung-Ang University, Seoul 06974, South Korea
2Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, South Korea
3Department of Food and Nutrition, Andong National University, Andong 36729, South Korea
*Correspondence: Jihoon Kim
Abstract
The lymphatic system plays a crucial role in maintaining physiological homeostasis and regulating immune responses. Traditional imaging modalities such as magnetic resonance imaging, computerized tomography, and positron emission tomography have been widely used to diagnose disorders in the lymphatic system, including lymphedema, lymphangioma, lymphatic metastasis, and Castleman disease. Nano-fluorescence technology has distinct advantages-including naked-eye visibility, operational simplicity, portability of the laser, and real-time visibility-and serves as an innovative alternative to traditional imaging techniques. This review explores recent advancements in nano-fluorescence imaging aimed at enhancing the resolution of lymphatic structure, function, and immunity. After delineating the fundamental characteristics of lymphatic systems, it elaborates on the development of various nano-fluorescence systems (including nanoparticles incorporating fluorescent dyes and those with intrinsic fluorescence) while addressing key challenges such as photobleaching, limited tissue penetration, biocompatibility, and signal interference from biomolecules. Furthermore, this review highlights the clinical applications of nano-fluorescence and its potential integration into standard diagnostic protocols. Ongoing advancements in nanoparticle technology underscore the potential of nano-fluorescence to revolutionize the diagnosis and treatment of lymphatic disease.
논문정보
- Review Paper
- 2024년 12월 (BRIC 등록일 2024-12-13)
- 국내 연구진
- 바이오·의료융합 > 다학제 융합/복합
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