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Alzheimers. Dement., Dec 06 2024, | https://doi.org/10.1002/alz.14426
Locus coeruleus tau is linked to successive cortical tau accumulation
Dahyun Yi 1, Min Soo Byun 2,3, Joon Hyung Jung 4, Gijung Jung 1, Hyejin Ahn 5, Yoon Young Chang 6, Musung Keum 7, Jun-Young Lee 8, Yun-Sang Lee 9, Yu Kyeong Kim 10, Koung Mi Kang 11,12, Chul-Ho Sohn 11,12, Shannon L Risacher 13,14,15, Andrew J Saykin 13,14,15,16, Dong Young Lee 1,2,3; KBASE Research Group
1Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Seoul, Republic of Korea.
2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.
3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
4Department of Psychiatry, Chungbuk National University Hospital, Cheongju-si, Republic of Korea.
5Interdisciplinary Program of Cognitive Science, Seoul National University College of Humanities, Seoul, Seoul, Republic of Korea.
6Inje University Sanggye Paik Hospital, Seoul, Seoul, Republic of Korea.
7Department of Neuropsychiatry, Soonchunhyang University Hospital, Bucheon-si, Gyeonggi-do, Republic of Korea.
8Department of Psychiatry, Seoul National University Boramae Medical Center, Seoul, Seoul, Republic of Korea.
9Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
10Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Seoul, Republic of Korea.
11Department of Radiology, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.
12Department of Radiology, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
13Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.
14Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
15Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
16Network Science Institute, Indiana University, Bloomington, Indiana, USA.
Corresponding Author : Dong Young Lee
1Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Seoul, Republic of Korea.
2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.
3Department of Psychiatry, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
4Department of Psychiatry, Chungbuk National University Hospital, Cheongju-si, Republic of Korea.
5Interdisciplinary Program of Cognitive Science, Seoul National University College of Humanities, Seoul, Seoul, Republic of Korea.
6Inje University Sanggye Paik Hospital, Seoul, Seoul, Republic of Korea.
7Department of Neuropsychiatry, Soonchunhyang University Hospital, Bucheon-si, Gyeonggi-do, Republic of Korea.
8Department of Psychiatry, Seoul National University Boramae Medical Center, Seoul, Seoul, Republic of Korea.
9Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
10Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Seoul, Republic of Korea.
11Department of Radiology, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.
12Department of Radiology, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
13Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.
14Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
15Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
16Network Science Institute, Indiana University, Bloomington, Indiana, USA.
Corresponding Author : Dong Young Lee
Abstract
Introduction: We investigated the hypothesis that tau burden in the locus coeruleus (LC) correlates with tau accumulation in cortical regions according to the Braak stages and examined whether the relationships differed according to cortical amyloid beta (Aβ) deposition.
Methods: One hundred and seventy well-characterized participants from an ongoing cohort were included. High-resolution T1, tau positron emission tomography (PET), and amyloid PET were obtained.
Results: LC tau burden was significantly linked to global tau in neocortical regions, as was tau in both early Braak stage (stage I/II) and later Braak stage areas. This relationship was significant only in Aβ-positive individuals. While LC tau did not directly impact memory, it was indirectly associated with delayed memory through mediation or moderation pathways.
Discussion: The findings from living human brains support the idea that LC tau closely relates to subsequent cortical tau accumulation, particularly among individuals with pathological Aβ accumulation, and identify LC tau burden as a promising indicator of cognitive trajectories of AD.
Highlights: Tau burden in the LC was significantly associated with cortical tau accumulation. Tau burden in SN or PPN showed no association with cortical tau accumulation. LC tau burden was serially associated with Braak stages. The tau-LC and cortical tau relationship was significant only in the Aβ-positive group. Cortical amyloid's impact on memory worsens with higher tau accumulation in the LC.
Methods: One hundred and seventy well-characterized participants from an ongoing cohort were included. High-resolution T1, tau positron emission tomography (PET), and amyloid PET were obtained.
Results: LC tau burden was significantly linked to global tau in neocortical regions, as was tau in both early Braak stage (stage I/II) and later Braak stage areas. This relationship was significant only in Aβ-positive individuals. While LC tau did not directly impact memory, it was indirectly associated with delayed memory through mediation or moderation pathways.
Discussion: The findings from living human brains support the idea that LC tau closely relates to subsequent cortical tau accumulation, particularly among individuals with pathological Aβ accumulation, and identify LC tau burden as a promising indicator of cognitive trajectories of AD.
Highlights: Tau burden in the LC was significantly associated with cortical tau accumulation. Tau burden in SN or PPN showed no association with cortical tau accumulation. LC tau burden was serially associated with Braak stages. The tau-LC and cortical tau relationship was significant only in the Aβ-positive group. Cortical amyloid's impact on memory worsens with higher tau accumulation in the LC.
논문정보
- Research article
- 2024년 12월 (BRIC 등록일 2024-12-18)
- 국내(교신)+국외 연구진
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