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한빛사논문

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김규리Gyuri Kim

동아대학교

CV File 223 kb

J. Hazard. Mater., Nov 29 2024, 484 S0304-3894(24)03286-2 | https://doi.org/10.1016/j.jhazmat.2024.136705 The impact of atmospheric ultrafine particulate matter on IgE-mediated type 1 hypersensitivity reaction

Jeong Won Park ^a,1, Minseong Kang ^a,1, Gyuri Kim ^a,1, Seung Yeun Hyun ^a, Juhyun Shin ^a, Seon Young Kim ^a, Jun Ho Lee ^b, Wahn Soo Choi^c, Jong-Ho Lee ^a,d, Kyuhong Lee ^e, Seok-Ho Kim^a, Wan-Seob Cho ^a, Hyuk Soon Kim ^a,d

^aDepartment of Health Sciences, The Graduate School of Dong-A University, Busan 49315, Republic of Korea
^bDepartment of Korean Medicine, College of Korean Medicine, Woosuk University, Jeonju 54986, Republic of Korea
^cDepartment of Immunology, College of Medicine, Konkuk University, Chungju 27478, Republic of Korea
dDepartment of Biomedical Sciences, College of Natural Science, Dong-A University, Busan 49315, Republic of Korea
^eInhalation Toxicology Center for Airborne Risk Factor, Korea Institute of Toxicology, 30 Baehak1-gil, Jeongeup, Jeollabuk-do 56212, Republic of Korea

¹JWP, MK, and GK contributed equally to this work.
Corresponding authors: Wan-Seob Cho, Hyuk Soon Kim

Abstract

The effect of atmospheric ultrafine particulate matter (UPM) on respiratory allergic diseases has been investigated for decades; however, the precise molecular mechanisms underlying these effects remain poorly understood. In this study, we used a simulated UPM (sUPM) generated via the spark discharge method to refine black carbon, a core particle that closely mimics real-world UPM, including the size (i.e., size of agglomerates: 165 nm) and organic carbon/elemental carbon ratio (i.e., 2.62). When 25 μg/mouse of dispersed sUPM was instilled into the lungs of mice, it promoted the infiltration and degranulation response of pulmonary mast cells, and exposure to sUPM in an immunoglobulin E (IgE)-mediated passive anaphylaxis model intensified the degranulation response of peripheral mast cells. These effects of sUPM were demonstrated to amplify the downstream signaling mechanism of the high-affinity IgE receptor (FcεRI) mediated by IgE when tested using rat basophil leukemia (RBL)-2H3 and mouse bone marrow-derived mast cells (BMMCs) collected from the bone marrow of BALB/c mice. These results indicate that airborne UPM can exacerbate type 1 hypersensitivity reactions by enhancing the IgE-mediated signaling pathways within mast cells. Furthermore, this study provided mechanistic evidence on exacerbated allergic pulmonary diseases induced by UPM inhalation.

논문정보

형식Research article
게재일2024년 11월 (BRIC 등록일 2024-12-09)
연구진국내 연구진
분야 생명과학 > 면역학

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