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고려대학교

J. Control. Release, Nov 27 2024, 377 S0168-3659(24)00799-5 | https://doi.org/10.1016/j.jconrel.2024.11.044 Stimuli-responsive and targeted nanomaterials: Revolutionizing the treatment of bacterial infections

Wen Li ^a,b,1, Qihang Ding^a,c,1, Meiqi Li ^a, Tianshou Zhang ^a, Chunyan Li ^a, Manlin Qi ^a, Biao Dong ^d, Jiao Fang ^a, Lin Wang ^a,b, Jong Seung Kim ^c

^aDepartment of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun 130021, China
^bKey Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, China
^cDepartment of Chemistry, Korea University, Seoul 02841, Republic of Korea
^dState Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130021, China

¹These authors contributed equally to this work.
Corresponding authors : Biao Dong, Jiao Fang, Lin Wang, Jong Seung Kim

Abstract

Bacterial infections have emerged as a major threat to global public health. The effectiveness of traditional antibiotic treatments is waning due to the increasing prevalence of antimicrobial resistance, leading to an urgent demand for alternative antibacterial technologies. In this context, antibacterial nanomaterials have proven to be powerful tools for treating antibiotic-resistant and recurring infections. Targeting nanomaterials not only enable the precise delivery of bactericidal agents but also ensure controlled release at the infection site, thereby reducing potential systemic side effects. This review collates and categorizes nanomaterial-based responsive and precision-targeted antibacterial strategies into three key types: exogenous stimuli-responsive (including light, ultrasound, magnetism), bacterial microenvironment-responsive (such as pH, enzymes, hypoxia), and targeted antibacterial action (involving electrostatic interaction, covalent bonding, receptor-ligand mechanisms). Furthermore, we discuss recent advances, potential mechanisms, and future prospects in responsive and targeted antimicrobial nanomaterials, aiming to provide a comprehensive overview of the field's development and inspire the formulation of novel, precision-targeted antimicrobial strategies.

논문정보

형식Review Paper
게재일2024년 11월 (BRIC 등록일 2024-12-09)
연구진국내(교신)+국외 연구진
분야 의약학 > 의약학 기타

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