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Clin. Nucl. Med., Dec 01 2024, 49 (12) | https://doi.org/10.1097/RLU.0000000000005457 Distinct Cognitive Trajectories According to Amyloid Positivity in Non-Alzheimer Disease Dementias

Jang, Hyemin MD^∗,†; Chun, Min Young MD^∗,‡,§; Yun, Jihwan MD^∗,∥; Kim, Jun Pyo MD^∗; Kang, Sung Hoon MD^¶; Kim, Hee Jin MD^{∗,∗∗,††,‡‡}; Na, Duk L. MD^∗,∗∗; Lee, Eun Hye MD^∗; Shin, Daeun MD^∗; Ham, Hongki MSc^{∗,∗∗,‡‡,§§}; Gu, Yuna MSc^∗,††; Kim, Chi-Hun MD^∥∥; Woo, Sook-Young PhD^¶¶; Seo, Sang Won MD^{∗,∗∗,††,‡‡,§§}; On Behalf of the K-ROAD Study Groups

From the ^∗Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
^†Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea
^‡Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea
^§Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Republic of Korea
^∥Department of Neurology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Republic of Korea
^¶Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea
^∗∗Alzheimer’s Disease Convergence Research Center, Samsung Medical Center, Seoul, Republic of Korea
^††Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea
^‡‡Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea
^§§Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea
^∥∥Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea
^¶¶Biomedical Statistics Center, Data Science Research Institute, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea.

H.J., M.C., and J.Y. contributed equally to this work and should be considered co-first authors.
S.W. and S.S. contributed equally to this work and should be considered co-corresponding authors.
Correspondence to: Sang Won Seo, MD, Sook-young Woo, PhD

Abstract

Background
The clinical effects of β-amyloid positivity (Aβ+) on copathologies in various dementias remain relatively underexamined. Thus, the present study was conducted to investigate the prevalence and clinical effects of Aβ+ in subcortical vascular cognitive impairment (SVCI) and frontotemporal dementia (FTD).

Patients and Methods
We enrolled SVCI (n = 583), FTD (n = 152), and cognitively unimpaired (CU) participants (n = 1,249) who underwent Aβ PET scans. The odds of having Aβ+ were subsequently compared among the diagnostic groups (CU, SVCI, and FTD) according to age and apolipoprotein E genotype. Additionally, a linear mixed-effects model was used to investigate the effects of Aβ+ on cognitive trajectories in SVCI and FTD.

Results
Compared with CU, the SVCI group had a higher prevalence of Aβ+ in the 75 to 90 years age group (adjusted odds ratio, 1.97; 95% confidence interval, 1.36–2.85; P < 0.001), as well as within the apolipoprotein E ε3/ε3 group (adjusted odds ratio, 1.78; 95% confidence interval, 1.20–2.63; P = 0.001), whereas the FTD group showed no difference in Aβ+ prevalence. Aβ+ was associated with a worse cognitive trajectory in SVCI (adjusted β-coefficient = −0.6424; P < 0.001), but not in FTD.

Conclusions
These findings contribute to our understanding of Aβ biomarker traits in various dementias in Korea.

논문정보

형식Research article
게재일2024년 12월 (BRIC 등록일 2024-12-05)
연구진국내 연구진
분야 의약학 > 신경의학

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