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Exp. Mol. Med., Dec 02 2024, | https://doi.org/10.1038/s12276-024-01354-4
Distribution and impact of p16INK4A+ senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction
Soon Sang Park1,2,7, Young-Kyoung Lee1,2,7, Young Hwa Kim1,7, So Hyun Park3, Hee Young Kang1,4, Jin Cheol Kim1,4, Dong Jun Kim2, Su Bin Lim1,2,5, Gyesoon Yoon1,2,5, Jang-Hee Kim3, Yong Won Choi1,6,8 and Tae Jun Park1,2,5,8
1Inflammaging Translational Research Center, Ajou University Medical Center, Suwon, Korea.
2Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
3Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
4Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
5Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.
6Department of Hematology and Oncology, Ajou University School of Medicine, Suwon, Korea.
7These authors contributed equally: Soon Sang Park, Young-Kyoung Lee, Young Hwa Kim.
8These authors jointly supervised this work: Yong Won Choi, Tae Jun Park
Corresponding authors
Correspondence to Yong Won Choi or Tae Jun Park.
1Inflammaging Translational Research Center, Ajou University Medical Center, Suwon, Korea.
2Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, Korea.
3Department of Pathology, Ajou University School of Medicine, Suwon, Korea.
4Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
5Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.
6Department of Hematology and Oncology, Ajou University School of Medicine, Suwon, Korea.
7These authors contributed equally: Soon Sang Park, Young-Kyoung Lee, Young Hwa Kim.
8These authors jointly supervised this work: Yong Won Choi, Tae Jun Park
Corresponding authors
Correspondence to Yong Won Choi or Tae Jun Park.
Abstract
Cellular senescence, recognized as a key hallmark of aging, leads to the accumulation of senescent cells in various tissues over time. While the detrimental effects of these cells on age-related pathological conditions are well-documented, there is still limited information about how senescent cells are distributed in normal tissues of both young and aged organs. Our research indicates that fully senescent p16INK4A+ cells are rarely identified in the parenchyma of organic tissues and in the stromal cells crucial for structural maintenance, such as fibroblasts and smooth muscle cells. Instead, p16INK4A+ cells are more commonly found in immune cells, whether they reside in the organ or are infiltrating. Notably, p16INK4A+ senescent T cells have been observed to induce apoptosis and inflammation in colonic epithelial cells through Granzyme A-PARs signaling, compromising the integrity of the epithelial lining. This study showed that the senescence of immune cells could affect the phenotypical change of the parenchymal cells in the elderly and suggests that targeting immunosenescence might be a strategy to control functional decline in this population.
논문정보
- Research article
- 2024년 12월 (BRIC 등록일 2024-12-31)
- 국내 연구진
- 의약학 > 종양의학
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