박준범 (서울대학교 의과대학, Harvard Medical School) | 한빛사논문 > 한빛사

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서울대학교 의과대학, Harvard Medical School

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Exp. Mol. Med., Dec 02 2024, | https://doi.org/10.1038/s12276-024-01358-0 Neddylation steers the fate of cellular receptors

Jun Bum Park^1,2,3, Min Young Lee^1,2, Jooseung Lee^1,2, Geon Ho Moon^1,2, Sung Joon Kim^1,2,4 and Yang-Sook Chun^1,2,4

¹Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.
²Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
³Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
⁴Department of Physiology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Corresponding author
Correspondence to Yang-Sook Chun.

Abstract

Cellular receptors regulate physiological responses by interacting with ligands, thus playing a crucial role in intercellular communication. Receptors are categorized on the basis of their location and engage in diverse biochemical mechanisms, which include posttranslational modifications (PTMs). Considering the broad impact and diversity of PTMs on cellular functions, we focus narrowly on neddylation, a modification closely resembling ubiquitination. We systematically organize its canonical and noncanonical roles in modulating proteins associated with cellular receptors with the goal of providing a more detailed perspective on the intricacies of both intracellular and cell-surface receptors.

논문정보

형식Review Paper
게재일2024년 12월 (BRIC 등록일 2024-12-04)
연구진국내(교신)+국외 연구진
분야 의약학 > 인체시스템의학

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