Masaud Shah (아주대학교) | 한빛사논문 > 한빛사

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Trends Pharmacol. Sci., Nov 26 2024, S0165-6147(24)00224-4 | https://doi.org/10.1016/j.tips.2024.10.013 Challenges and considerations in multi-epitope vaccine design surrounding toll-like receptors

Masaud Shah ^1,2, Sobia Rafiq 1, Hyun G. Woo ^1,2,3

¹Department of Physiology, Ajou University School of Medicine, Suwon 16499, Republic of Korea
²Ajou Translational Omics Center (ATOC), Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon, Republic of Korea
³Department of Biomedical Science, Graduate School, Ajou University, Suwon 16499, Republic of Korea

Correspondence: Hyun G. Woo

Abstract

Epitope-based peptide vaccines elicit targeted immune responses, making them effective for diseases requiring focused immune activation, such as targeting cancer-associated antigens. Strategies like peptide cocktails and mRNA-based epitope vaccines have revolutionized the field; however, the term 'multi-epitope peptide vaccine' has been overextended, especially concerning the use of toll-like receptors (TLRs), their ligands, and peptide linkers. TLRs are often conflated with T cell receptors (TCRs) and B cell receptors (BCRs), which recognize immunogenic peptides within vaccines. This Opinion clarifies the role of TLRs and highlights challenges linked to their indiscriminate use in multi-epitope vaccine design. While peptide linkers are crucial in creating multivalent vaccines, their unsupervised application is increasing and warrants attention. After highlighting their role in advancing peptide vaccines, we discuss critical factors in linker implementation and caution against their misuse, which could undermine vaccines' efficacy.

논문정보

형식Review Paper
게재일2024년 11월 (BRIC 등록일 2024-12-04)
연구진국내 연구진
분야 의약학 > 감염의학

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