한빛사
>
한빛사논문
한빛사논문
- 조회271
Nat. Commun., Nov 30 2024, 15 (1) 10423 | https://doi.org/10.1038/s41467-024-54759-0
Transcranial optogenetic brain modulator for precise bimodal neuromodulation in multiple brain regions
Hyogeun Shin1, Min-Ho Nam2, Seung Eun Lee3, Soo Hyun Yang4,5, Esther Yang4,5, Jin Taek Jung4,5, Hyun Kim4,5, Jiwan Woo3, Yakdol Cho3, Youngsam Yoon6 & Il-Joo Cho4,5,7
1School of Electronic and Electrical Engineering, College of IT Engineering, Kyungpook National University, Daegu, Republic of Korea.
2Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
3Research Animal Resources Center, Research Resources Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
4Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
5Department of Anatomy, College of Medicine, Korea University, Seoul, Republic of Korea.
6Department of Electrical Engineering, Korea Military Academy, Seoul, Republic of Korea.
7Department of Convergence Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Corresponding author
Correspondence to Il-Joo Cho.
1School of Electronic and Electrical Engineering, College of IT Engineering, Kyungpook National University, Daegu, Republic of Korea.
2Center for Brain Function, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
3Research Animal Resources Center, Research Resources Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
4Department of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea.
5Department of Anatomy, College of Medicine, Korea University, Seoul, Republic of Korea.
6Department of Electrical Engineering, Korea Military Academy, Seoul, Republic of Korea.
7Department of Convergence Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
Corresponding author
Correspondence to Il-Joo Cho.
Abstract
Transcranial brain stimulation is a promising technology for safe modulation of brain function without invasive procedures. Recent advances in transcranial optogenetic techniques with external light sources, using upconversion particles and highly sensitive opsins, have shown promise for precise neuromodulation with improved spatial resolution in deeper brain regions. However, these methods have not yet been used to selectively excite or inhibit specific neural populations in multiple brain regions. In this study, we created a wireless transcranial optogenetic brain modulator that combines highly sensitive opsins and upconversion particles and allows for precise bimodal neuromodulation of multiple brain regions without optical crosstalk. We demonstrate the feasibility of our approach in freely behaving mice. Furthermore, we demonstrate its usefulness in studies of complex behaviors and brain dysfunction by controlling extorting behavior in mice in food competition tests and alleviating the symptoms of Parkinson's disease. Our approach has potential applications in the study of neural circuits and development of treatments for various brain disorders.
논문정보
- Research article
- 2024년 11월 (BRIC 등록일 2024-12-03)
- 국내 연구진
- 바이오·의료융합 > 의료기기
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
