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Nat. Commun., 29 November 2024 | https://doi.org/10.1038/s41467-024-54620-4
A vaccine platform targeting lung-resident memory CD4+ T-cells provides protection against heterosubtypic influenza infections in mice and ferrets
Kwang Hyun Ko 1,2, Hyun Shik Bae 1, Jeong Woo Park 2,3, Jin-Sun Lee 2,3, Somin Park 3, Jun Heo 4, Hyunsoo Park 4, Jaeseok Choi 5, Eunseo Bae 5, Woonsung Na 5, Seong-Hyun Park 6, Baik-Lin Seong 7, Seung Hyun Han 2,3, Dong-Ho Kim 1,8,* & Seung Bin Cha 1,8,*
1R&D Center, NA Vaccine Institute, Seoul 05854, Republic of Korea.
2Interdisciplinary Program in Genetic Engineering, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
3Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Republic of Korea.
4Vaccine R&D Team, Central Institute, Il-Yang Pharmaceutical, Yongin 17096, Republic of Korea.
5College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
6Graduate Program in Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University, Seoul 08826, Republic of Korea.
7Department of Microbiology and Immunology, Yonsei University College of Medicine, Seodaemun-gu, Seoul 08826, Republic of Korea.
8These authors contributed equally: Dong-Ho Kim, Seung Bin Cha.
2Interdisciplinary Program in Genetic Engineering, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea.
3Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Republic of Korea.
4Vaccine R&D Team, Central Institute, Il-Yang Pharmaceutical, Yongin 17096, Republic of Korea.
5College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
6Graduate Program in Biomaterials Science and Engineering, College of Life Science and Biotechnology, Yonsei University, Seoul 08826, Republic of Korea.
7Department of Microbiology and Immunology, Yonsei University College of Medicine, Seodaemun-gu, Seoul 08826, Republic of Korea.
8These authors contributed equally: Dong-Ho Kim, Seung Bin Cha.
*Corresponding authors: correspondence to Dong-Ho Kim or Seung Bin Cha
Abstract
Lung tissue-resident memory T (TRM) cells induced by influenza vaccination are crucial for heterosubtypic immunity upon re-exposure to the influenza virus, enabling rapid and robust responses upon reactivation. To enhance the efficacy of influenza vaccines, we induce the generation of lung TRM cells following intranasal vaccination with a commercial influenza vaccine adjuvanted with NexaVant (NVT), a TLR3 agonist-based adjuvant. We demonstrate that intranasal immunization with the NVT-adjuvanted vaccine provides improved protection against influenza virus infections by inducing the generation of CD4+ TRM cells in the lungs in a type I interferon-dependent manner. These pulmonary CD4+ TRM cells provide potent mucosal immunity and cross-protection against heterosubtypic infections in both mouse and ferret models. This vaccine platform has the potential to significantly improve conventional intramuscular influenza vaccines by providing broader protection.
논문정보
- Research article
- 2024년 11월 (BRIC 등록일 2024-11-29)
- 국내 연구진
- 생명과학 > 면역학
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