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한국생명공학연구원

Bioresour. Technol., Nov 2024, 412 S0960-8524(24)01112-X | https://doi.org/10.1016/j.biortech.2024.131408 Long-term acclimation to organic carbon enhances the production of loliolide from Scenedesmus deserticola

Dae-Hyun Cho ^a,1, Jin-Ho Yun^a,b,c,1, Dong-Yoon Choi ^a, Jina Heo ^d, Eun Kyung Kim ^a, Juran Ha ^a, Chan Yoo ^e, Hong Il Choi ^a,b, Yong Jae Lee ^a,b, Hee-Sik Kim ^a,b,e

^aCell Factory Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea
^bDepartment of Environmental Biotechnology, KRIBB School of Biotechnology, University of Science & Technology (UST), Daejeon 34113, Republic of Korea
^cDepartment of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Republic of Korea
^dDepartment of Economy and Future Strategy Research, CRI, Cheongju 28517, Republic of Korea
^eASK LABS, KRIBB BVC Center 109, Daejeon 34141, Republic of Korea

¹These authors contributed equally to this work.
Corresponding author : Hee-Sik Kim

Abstract

Production of functional biocompounds from microalgae has garnered interest from different industrial sectors; however, their overall productivity must be substantially improved for commercialization. Herein, long-term acclimation of Scenedesmus deserticola was conducted using glucose as an organic carbon source to enhance its heterotrophic capabilities and the production potential of loliolide. A year-long acclimation on agar plates led to the selection of S. deserticola HS4, which exhibited at least 2-fold increase in loliolide production potential; S. deserticola HS4 was subjected to further screening of its cultivation conditions and fed-batch cultivation was subsequently performed in liter-scale reactors. While S. deserticola HS4 exhibited shifts in cellular morphology and biochemical composition, the results suggested a substantial increase in its loliolide productivity regardless of trophic modes. Collectively, these results highlight the potential of long-term acclimation as an effective strategy for improving microalgal crops to align with industrial production practices.

논문정보

형식Research article
게재일2024년 11월 (BRIC 등록일 2024-11-28)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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