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한빛사논문
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Nano Converg., Nov 26 2024, 11 (1) | https://doi.org/10.1186/s40580-024-00455-0
Integration of nanobiosensors into organ-on-chip systems for monitoring viral infections
Jiande Zhang1, Min-Hyeok Kim1, Seulgi Lee2 and Sungsu Park1,2,3*
1School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea
2Department of Metabiohealth, Sungkyunkwan University (SKKU), Suwon 16419, Korea
3Department of Biophysics, Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 16419, Korea
*Correspondence: Sungsu Park
1School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea
2Department of Metabiohealth, Sungkyunkwan University (SKKU), Suwon 16419, Korea
3Department of Biophysics, Institute of Quantum Biophysics (IQB), Sungkyunkwan University (SKKU), Suwon 16419, Korea
*Correspondence: Sungsu Park
Abstract
The integration of nanobiosensors into organ-on-chip (OoC) models offers a promising advancement in the study of viral infections and therapeutic development. Conventional research methods for studying viral infection, such as two-dimensional cell cultures and animal models, face challenges in replicating the complex and dynamic nature of human tissues. In contrast, OoC systems provide more accurate, physiologically relevant models for investigating viral infections, disease mechanisms, and host responses. Nanobiosensors, with their miniaturized designs and enhanced sensitivity, enable real-time, continuous, in situ monitoring of key biomarkers, such as cytokines and proteins within these systems. This review highlights the need for integrating nanobiosensors into OoC systems to advance virological research and improve therapeutic outcomes. Although there is extensive literature on biosensors for viral infection detection and OoC models for replicating infections, real integration of biosensors into OoCs for continuous monitoring remains unachieved. We discuss the advantages of nanobiosensor integration for real-time tracking of critical biomarkers within OoC models, key biosensor technologies, and current OoC systems relevant to viral infection studies. Additionally, we address the main technical challenges and propose solutions for successful integration. This review aims to guide the development of biosensor-integrated OoCs, paving the way for precise diagnostics and personalized treatments in virological research.
논문정보
- Review Paper
- 2024년 11월 (BRIC 등록일 2024-11-27)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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