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- 조회475
Genes Dev., November 21, 2024 | http://www.genesdev.org/cgi/doi/10.1101/gad.352084.124
mTORC1, the maestro of cell metabolism and growth
Long He 1,2,3,*, Sungyun Cho 1,2,3 and John Blenis 1,2,*
1Meyer Cancer Center, Weill Cornell Medicine, New York, New York 10021, USA;
2Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, USA
3These authors contributed equally to this work.
2Department of Pharmacology, Weill Cornell Medicine, New York, New York 10021, USA
3These authors contributed equally to this work.
*Corresponding authors: correspondence to Long He or John Blenis
Abstract
The mechanistic target of rapamycin (mTOR) pathway senses and integrates various environmental and intracellular cues to regulate cell growth and proliferation. As a key conductor of the balance between anabolic and catabolic processes, mTOR complex 1 (mTORC1) orchestrates the symphonic regulation of glycolysis, nucleic acid and lipid metabolism, protein translation and degradation, and gene expression. Dysregulation of the mTOR pathway is linked to numerous human diseases, including cancer, neurodegenerative disorders, obesity, diabetes, and aging. This review provides an in-depth understanding of how nutrients and growth signals are coordinated to influence mTOR signaling and the extensive metabolic rewiring under its command. Additionally, we discuss the use of mTORC1 inhibitors in various aging-associated metabolic diseases and the current and future potential for targeting mTOR in clinical settings. By deciphering the complex landscape of mTORC1 signaling, this review aims to inform novel therapeutic strategies and provide a road map for future research endeavors in this dynamic and rapidly evolving field.
논문정보
- Review Paper
- 2024년 11월 (BRIC 등록일 2024-11-25)
- 국외 연구진
- 생명과학 > 세포생물학
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