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Qihang DingQihang Ding

고려대학교

Biomaterials, Nov 15 2024, 315 S0142-9612(24)00503-9 | https://doi.org/10.1016/j.biomaterials.2024.122968 Self-propelling intelligent nanomotor: A dual-action photothermal and starvation strategy for targeted deep tumor destruction

Ling Mei ^a,1, Qihang Ding ^b,1, Yuxin Xie ^a,1, Haowei Liu ^a, Hongping Li ^a, Eunji Kim ^b, Xue Shen ^a, Yibin Zhang ^a, Shuai Zhang ^c, Jong Seung Kim ^b

^aEngineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu, 610106, China
^bDepartment of Chemistry, Korea University, Seoul, 02841, South Korea
^cDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, 150 Haping Road Nangang District, Harbin, Heilongjiang Province, 150040, China

¹These authors (L. M., Q. D and Y. X.) contribute equally to this work.
Corresponding authors: Yibin Zhang, Shuai Zhang, Jong Seung Kim

Abstract

Delivering nanoparticles to deep tumor tissues while maintaining high therapeutic efficacy and minimizing damage to surrounding tissues has long posed a significant challenge. To address this, we have developed innovative self-propelling bowl-shaped nanomotors MSLA@GOx-PDA composed of mesoporous silica loaded with l-arginine and polydopamine, along with glucose oxidase (GOx). These nanomotors facilitate the generation of hydrogen peroxide through GOx-catalyzed glucose oxidation, thereby initiating nitric oxide production from l-arginine. This dual mechanism equips MSLA@GOx-PDA with the robust motility required for deep tumor tissue penetration while depleting essential nutrients necessary for tumor growth, consequently impeding tumor progression. In addition, near-infrared lasers have the significant advantage of being depth-penetrating and non-invasive, allowing real-time fluorescence imaging and guiding dopamine-mediated mild photothermal therapy. Notably, starvation therapy depletes intracellular adenosine triphosphate and inhibits the synthesis of heat shock proteins, thus overcoming the Achilles' heel of mild photothermal therapy and significantly enhancing the efficacy of this therapy with encouraging synergistic anti-tumour effects. Overall, the integration of biochemical and optics strategies in this nanomotor platform represents a significant advancement in deep-tissue tumor therapy. It has substantial clinical translational value and is expected to have a transformative impact on future cancer treatments.

논문정보

형식Research article
게재일2024년 11월 (BRIC 등록일 2024-11-21)
연구진국내(교신)+국외 연구진
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