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Nat. Neurosci., Published online: 19 November 2024 | https://doi.org/10.1038/s41593-024-01799-w
A top-down slow breathing circuit that alleviates negative affect in mice
Jinho Jhang1, Seahyung Park1, Shijia Liu1,2,6, David D. O’Keefe3 & Sung Han1,2,4,5
1Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
2Department of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
3Research Development Department, The Salk Institute for Biological Studies, La Jolla, CA, USA.
4Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
5Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
6Present address: Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Corresponding author
Correspondence to Sung Han.
1Peptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
2Department of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA.
3Research Development Department, The Salk Institute for Biological Studies, La Jolla, CA, USA.
4Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
5Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
6Present address: Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Corresponding author
Correspondence to Sung Han.
Abstract
Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a top-down breathing pathway from dorsal anterior cingulate cortex (dACC) neurons to pontine reticular nucleus GABAergic inhibitory neurons (PnCGABA), which then project to the ventrolateral medulla (VLM). dACC→PnC activity correlates with slow breathing cycles and volitional orofacial behaviors and is influenced by anxiogenic conditions. Optogenetic stimulation of the dACC→PnCGABA→VLM circuit simultaneously slows breathing and suppresses anxiety-like behaviors, whereas optogenetic inhibition increases both breathing rate and anxiety-like behaviors. These findings suggest that the dACC→PnCGABA→VLM circuit has a crucial role in coordinating slow breathing and reducing negative affect. Our study elucidates a circuit basis for top-down control of breathing, which can influence emotional states.
논문정보
- Research article
- 2024년 11월 (BRIC 등록일 2024-11-20)
- 국내(교신)+국외 연구진
- 생명과학 > 신경생물학
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