한빛사
>
한빛사논문
한빛사논문
1
- 조회760
Nature, Nov 13 2024, | https://doi.org/10.1038/s41586-024-08163-9
Adult skull bone marrow is an expanding and resilient haematopoietic reservoir
Bong Ihn Koh1, Vishal Mohanakrishnan1, Hyun-Woo Jeong2, Hongryeol Park1, Kai Kruse3, Young Jun Choi4, Melina Nieminen-Kelhä5, Rahul Kumar6, Raquel S. Pereira7, Susanne Adams1, Hyuek Jong Lee8, M. Gabriele Bixel1, Peter Vajkoczy5, Daniela S. Krause6 & Ralf H. Adams1
1Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
2Sequencing Core Facility, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
3Bioinformatics Service Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
4Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
5Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and HumboldtUniversität zu Berlin, Berlin, Germany.
6Institute of Transfusion Medicine, Transfusion Center, University Medicine Mainz, Mainz, Germany.
7Georg-Speyer-Haus Institute for Tumor Biology and Experimental Medicine and Goethe University Frankfurt, Frankfurt, Germany.
8Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.
Corresponding authors
Correspondence to Bong Ihn Koh or Ralf H. Adams.
1Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
2Sequencing Core Facility, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
3Bioinformatics Service Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
4Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
5Department of Neurosurgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and HumboldtUniversität zu Berlin, Berlin, Germany.
6Institute of Transfusion Medicine, Transfusion Center, University Medicine Mainz, Mainz, Germany.
7Georg-Speyer-Haus Institute for Tumor Biology and Experimental Medicine and Goethe University Frankfurt, Frankfurt, Germany.
8Center for Vascular Research, Institute for Basic Science, Daejeon, Republic of Korea.
Corresponding authors
Correspondence to Bong Ihn Koh or Ralf H. Adams.
Abstract
The bone marrow microenvironment is a critical regulator of haematopoietic stem cell self-renewal and fate1. Although it is appreciated that ageing, chronic inflammation and other insults compromise bone marrow function and thereby negatively affect haematopoiesis2, it is not known whether different bone compartments exhibit distinct microenvironmental properties and functional resilience. Here we use imaging, pharmacological approaches and mouse genetics to uncover specialized properties of bone marrow in adult and ageing skull. Specifically, we show that the skull bone marrow undergoes lifelong expansion involving vascular growth, which results in an increasing contribution to total haematopoietic output. Furthermore, skull is largely protected against major hallmarks of ageing, including upregulation of pro-inflammatory cytokines, adipogenesis and loss of vascular integrity. Conspicuous rapid and dynamic changes to the skull vasculature and bone marrow are induced by physiological alterations, namely pregnancy, but also pathological challenges, such as stroke and experimental chronic myeloid leukaemia. These responses are highly distinct from femur, the most extensively studied bone marrow compartment. We propose that skull harbours a protected and dynamically expanding bone marrow microenvironment, which is relevant for experimental studies and, potentially, for clinical treatments in humans.
논문정보
- Research article
- 2024년 11월 (BRIC 등록일 2024-11-18)
- 국내+국외 연구진
- 생명과학 > 생명과학 기타
댓글 작성 로그인
팝업 닫기관련 링크
연구자 키워드
소속기관 논문보기
관련분야 논문보기
해당논문 저자보기
