한빛사논문
Donggue Kim1, Ji Woo Lee1, Yang Tae Kim2, Junhyeok Choe1, Gaeun Kim1, Chang Man Ha3, Jae Geun Kim2,4, Kwang Hoon Song1,4, Sunggu Yang1,4,5
1Department of Nano-Bioengineering, Incheon National University, Incheon, 22012 Republic of Korea
2Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, 22012 Republic of Korea
3Research Division and Brain Research Core Facilities of Korea Brain Research Institute, Daegu, 41068 Republic of Korea
4Research Center of Brain-Machine Interface, Incheon National University, Incheon, 22012 Republic of Korea
5gBrain Inc., Incheon, 21984 Republic of Korea
Corresponding Authors: Jae Geun Kim, Kwang Hoon Song, Sunggu Yang
Abstract
Ischemic stroke (IS) accounts for most stroke incidents and causes intractable damage to brain tissue. This condition manifests as diverse aftereffects, such as motor impairment, emotional disturbances, and dementia. However, a fundamental approach to curing IS remains unclear. This study proposes a novel approach for treating IS by employing minimally invasive and injectable jammed gelatin-norbornene nanofibrous hydrogels (GNF) infused with growth factors (GFs). The developed GNF/GF hydrogels are administered to the motor cortex of a rat IS model to evaluate their therapeutic effects on IS-induced motor dysfunction. GNFs mimic a natural fibrous extracellular matrix architecture and can be precisely injected into a targeted brain area. The syringe-injectable jammed nanofibrous hydrogel system increased angiogenesis, inflammation, and sensorimotor function in the IS-affected brain. For clinical applications, the biocompatible GNF hydrogel has the potential to efficiently load disease-specific drugs, enabling targeted therapy for treating a wide range of neurological diseases.
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