한빛사논문
Soumilee Chaudhuri1,2,3 Desarae A. Dempsey1,2,3 Yen-Ning Huang1,2 Tamina Park1,2 Sha Cao2,4 Evgeny J. Chumin1,2 Hannah Craft1,2 Paul K. Crane5 Shubhabrata Mukherjee5 Seo-Eun Choi5 Phoebe Scollard5 Michael Lee5 Connie Nakano5 Jesse Mez6 Emily H. Trittschuh7,8 Brandon S. Klinedinst9 Timothy J. Hohman10 Jun-Young Lee11 Koung Mi Kang12 Chul-Ho Sohn12 Yu Kyeong Kim13 Dahyun Yi14 Min Soo Byun15,16 Shannon L. Risacher1,2,3 Kwangsik Nho1,2,17 Andrew J. Saykin1,2,3,18 Dong Young Lee14,15,16 for the KBASE Research Group
1Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA
2Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
3Medical Neuroscience Graduate Program, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA
4Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA
5Department of Medicine, University of Washington, Seattle, Washington, USA
6Department of Neurology, Boston University, Boston, Massachusetts, USA
7Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
8Geriatrics Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
9Department of General Internal Medicine, Harborview Medical Center, University of Washington School of Medicine, Seattle, Washington, USA
10Vanderbilt Memory & Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
11Department of Neuropsychiatry, SMGSNU Boramae Medical Center, Dongjak-gu, Seoul, Republic of Korea
12Department of Radiology, Seoul National University Hospital, Jongno-gu, Seoul, Republic of Korea
13Department of Nuclear Medicine, SMGSNU Boramae Medical Center, Dongjak-gu, Seoul, Republic of Korea
14Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Jongno-gu, Seoul, Republic of Korea
15Department of Neuropsychiatry, Seoul National University Hospital, Jongno-gu, Seoul, Republic of Korea
16Department of Psychiatry, Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea
17School of Informatics and Computing, Indiana University, Indianapolis, Indiana, USA
18Department of Medical and Molecular Genetics, Medical Research and Library Building, Indiana University School of Medicine, Indianapolis, Indiana, USA
Soumilee Chaudhuri and Desarae A. Dempsey contributed equally to this study.
Correspondence : Andrew J. Saykin and Kwangsik Nho, Dong Young Lee
Abstract
BACKGROUND
Limited research has explored the effect of cardiovascular risk and amyloid interplay on cognitive decline in East Asians.
METHODS
Vascular burden was quantified using Framingham's General Cardiovascular Risk Score (FRS) in 526 Korean Brain Aging Study (KBASE) participants. Cognitive differences in groups stratified by FRS and amyloid positivity were assessed at baseline and longitudinally.
RESULTS
Baseline analyses revealed that amyloid-negative (Aβ–) cognitively normal (CN) individuals with high FRS had lower cognition compared to Aβ– CN individuals with low FRS (p < 0.0001). Longitudinally, amyloid pathology predominantly drove cognitive decline, while FRS alone had negligible effects on cognition in CN and mild cognitive impairment (MCI) groups.
CONCLUSION
Our findings indicate that managing vascular risk may be crucial in preserving cognition in Aβ– individuals early on and before the clinical manifestation of dementia. Within the CN and MCI groups, irrespective of FRS status, amyloid-positive individuals had worse cognitive performance than Aβ– individuals.
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