한빛사논문
- 조회650
Michael R. Williamson1,2,3,6, Wookbong Kwon1,2,3,6, Junsung Woo1,2,3, Yeunjung Ko1,2,4, Ehson Maleki1,2, Kwanha Yu1,2,3, Sanjana Murali1,2,5, Debosmita Sardar1,2,3 & Benjamin Deneen1,2,3,4,5
1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA.
2Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA.
3Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
4Program in Immunology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
5Program in Cancer Cell Biology, Baylor College of Medicine, Houston, TX, USA.
6These authors contributed equally: Michael R. Williamson, Wookbong Kwon.
Corresponding author
Correspondence to Benjamin Deneen.
Abstract
The physical manifestations of memory formation and recall are fundamental questions that remain unresolved1. At the cellular level, ensembles of neurons called engrams are activated by learning events and control memory recall1,2,3,4,5. Astrocytes are found in close proximity to neurons and engage in a range of activities that support neurotransmission and circuit plasticity6,7,8,9,10. Moreover, astrocytes exhibit experience-dependent plasticity11,12,13, although whether specific ensembles of astrocytes participate in memory recall remains obscure. Here we show that learning events induce c-Fos expression in a subset of hippocampal astrocytes, and that this subsequently regulates the function of the hippocampal circuit in mice. Intersectional labelling of astrocyte ensembles with c-Fos after learning events shows that they are closely affiliated with engram neurons, and reactivation of these astrocyte ensembles stimulates memory recall. At the molecular level, learning-associated astrocyte (LAA) ensembles exhibit elevated expression of nuclear factor I-A, and its selective deletion from this population suppresses memory recall. Taken together, our data identify LAA ensembles as a form of plasticity that is sufficient to provoke memory recall and indicate that astrocytes are an active component of the engram.
논문정보
- Research article
- 2024년 11월 (BRIC 등록일 2024-11-08)
- 국외 연구진
- 생명과학 > 신경생물학
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