한빛사논문
- 조회308
Tae-Su Han 1,2,3, Dae-Soo Kim 1,2,*, Mi-Young Son 1,2,3,* and Hyun-Soo Cho 1,2,3,*
1Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.
2Korea University of Science and Technology, Daejeon 34316, Republic of Korea.
3Department of Biological Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
*Corresponding authors: correspondence to Dae-Soo Kim, Mi-Young Son or Hyun-Soo Cho
Abstract
Epigenetic modifiers (miRNAs, histone methyltransferases (HMTs)/demethylases, and DNA methyltransferases/demethylases) are associated with cancer proliferation, metastasis, angiogenesis, and drug resistance. Among these modifiers, HMTs are frequently overexpressed in various cancers, and recent studies have increasingly identified these proteins as potential therapeutic targets. In this review, we discuss members of the SET and MYND domain-containing protein (SMYD) family that are topics of extensive research on the histone methylation and nonhistone methylation of cancer-related genes. Various members of the SMYD family play significant roles in cancer proliferation, metastasis, and drug resistance by regulating cancer-specific histone methylation and nonhistone methylation. Thus, the development of specific inhibitors that target SMYD family members may lead to the development of cancer treatments, and combination therapy with various anticancer therapeutic agents may increase treatment efficacy.
논문정보
- Review Paper
- 2024년 11월 (BRIC 등록일 2024-11-01)
- 국내 연구진
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