오정주 (Delft University of Technology) | 한빛사논문 > 한빛사

한빛사논문

조회578

오정주Jeong-Joo Oh

Delft University of Technology

CV File

Trends Biotechnol., Oct 29 2024, S0167-7799(24)00280-4 | https://doi.org/10.1016/j.tibtech.2024.09.018 Leveraging the versatile properties of bacterial spores in materials

Likhitha Reddy Kummetha ^1,2, Jeong-Joo Oh ^1,2,*, Franka H. van der Linden ¹, and Marie-Eve Aubin-Tam^1,*

¹Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, Delft 2629, HZ, the Netherlands

²These authors contributed equally

*Correspondence: J.-J. Oh and M.-E. Aubin-Tam

Abstract

Inspired by biological functions of living systems, researchers have engineered cells as independent functional materials or integrated them within a natural or synthetic matrix to create engineered living materials (ELMs). However, the 'livingness' of cells in such materials poses serious drawbacks, such as a short lifespan and the need for cold-chain logistics. Bacterial spores have emerged as a game changer to bypass these shortcomings as a result of their intrinsic dormancy and resistance against harsh conditions. Emerging synthetic biology tools tailored for engineering spores and better understanding of their physical properties have led to novel applications of spore-based materials. Here, we review recent advances in such materials and discuss future challenges for the development of time- and cost-efficient spore-based materials with high performance.

논문정보