남가은 (고려대학교 의과대학) | 한빛사논문 > 한빛사

한빛사논문

조회298

고려대학교 의과대학

Br. J. Sports Med., Oct 29 2024, bjsports-2024-108264 | https://doi.org/10.1136/bjsports-2024-108264 Changes in physical activity and all-cause mortality among individuals with dementia: a cohort study using the National Health Insurance Service Database in Korea

Kye-Yeung Park¹, Youn Huh², Ga Eun Nam³, Kyungdo Han⁴, Jin-Hyung Jung⁵, Yoon Jeong Cho⁶, Seon Mee Kim³, Hwan-Sik Hwang¹, Yong-Moon Mark Park^7,8

1Department of Family Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea

2Department of Family Medicine, Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi-do, Republic of Korea

3Department of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea

4Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea

5Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

6Department of Family Medicine, Daegu Catholic University School of Medicine, Daegu, Republic of Korea

7Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA

8Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA

K-YP and YH contributed equally.

Correspondence to Ga Eun Nam; Yong-Moon Mark Park

Abstract

To examine associations between the amount and changes in regular physical activity (PA) before and after diagnosis of dementia and all-cause mortality risk, and whether these associations differ by PA intensity (light, moderate or vigorous). This retrospective cohort study used data from the Korean National Health Insurance Service Database, including 60 252 individuals newly diagnosed with dementia between 2010 and 2016 who underwent health examinations both before and after diagnosis. PA was assessed using the International Physical Activity Questionnaire-Short Form. Multivariable Cox proportional hazards regression models were used to analyse the associations between PA (amount and changes) and all-cause mortality risk. During a mean follow-up of 3.7 years, 16 431 (27.3%) deaths occurred. Higher PA levels after dementia diagnosis were associated with a dose-dependent decrease in mortality risk (p for trend <0.001). Maintaining regular PA, compared with remaining inactive, was associated with the lowest mortality risk (HR=0.71, 95% CI 0.65 to 0.79). Sustained engagement in PA of any intensity was associated with decreased mortality risk: light (HR=0.70, 95% CI 0.67 to 0.75), moderate (HR=0.74, 95% CI 0.64 to 0.86) and vigorous PA (HR=0.70, 95% CI 0.61 to 0.79). Initiating any PA intensity after dementia diagnosis was associated with at least 20% reduced mortality risk. These associations were consistent in Alzheimer's disease. Maintaining or initiating regular PA, regardless of intensity, after dementia diagnosis was associated with a reduced risk of all-cause mortality. Lifestyle modifications promoting PA might offer survival benefits for individuals with dementia.

논문정보

형식Research article
게재일2024년 10월 (BRIC 등록일 2024-10-31)
연구진국내(교신)+국외 연구진
분야 의약학 > 의약학 기타

댓글 작성 로그인

CV 열람하기

연락처 보기