한빛사논문
- 조회112
Woojin Choi 1,8, Utkarsh Mangal 2,8, Jae-Hun Yu 3, Jeong-Hyun Ryu 3, Ji‑Yeong Kim 3, Taesuk Jun 1, Yoojin Lee 1, Heesu Cho 1, Moonhyun Choi 1, Milae Lee 1, Du Yeol Ryu 1, Sang-Young Lee 1, Se Yong Jung 4, Jae-Kook Cha 5,6, Jung Yul Cha 3, Kee-Joon Lee 3, Sangmin Lee 7, Sung-Hwan Choi 3,* & Jinkee Hong 1,*
1Department of Chemical and Biomolecular Engineering, College of Engineering, Yonsei University, Seoul, Republic of Korea. 2BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, Korea.
3Department of Orthodontics, Institute of Craniofacial Deformity, Yonsei University College of Dentistry, Seoul, Republic of Korea.
4Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.
5Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Republic of Korea.
6Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, USA.
7School of Mechanical Engineering, Chung-ang University, 84, Heukserok-ro, Dongjak-gu, Seoul, Republic of Korea.
8These authors contributed equally: Woojin Choi, Utkarsh Mangal.
*Corresponding authors: correspondence to Sung-Hwan Choi or Jinkee Hong
Abstract
Medical plastic-appliance-based healthcare services, especially in dentistry, generate tremendous amounts of plastic waste. Given the physiological features of our mouth, it is desirable to substitute dental care plastics with viscoelastic and antimicrobial bioplastics. Herein, we develop a medical-grade and sustainable bioplastic that is viscoelastic enough to align the tooth positions, resists microbial contamination, and exhibits recyclable life cycles. In particular, we devise a molecular template involving entanglement-inducing and antimicrobial groups and prepare a silk fibroin-based dental care bioplastic. The generated compactly entangled structure endows great flexibility, toughness, and viscoelasticity. Therefore, a satisfactory orthodontic outcome is accomplished, as demonstrated by the progressive alignment of male rabbit incisors within the 2.5 mm range. Moreover, the prepared bioplastic exhibits resistance to pathogenic colonization of intraoral microbes such as Streptococcaceae and Veillonellaceae. Because the disentanglement of entangled domains enables selective separation and extraction of the components, the bioplastic can be recycled into a mechanically identical one. The proposed medical-grade and sustainable bioplastic could potentially contribute to a green healthcare future.
논문정보
- Research article
- 2024년 10월 (BRIC 등록일 2024-10-25)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 의료기기
관련 보도자료
- Bio통신원
- 2024. 10. 29
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