한빛사논문
- 조회331
Massimo M. Onesto 1,2,3, Ji-il Kim 1,2,3, Sergiu P. Pasca 1,2,*
1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
2Stanford Brain Organogenesis, Wu Tsai Neurosciences Institute and Bio-X, Stanford University, Stanford, CA, USA
3These authors contributed equally
*Corresponding author: correspondence to Sergiu P. Pasca
Abstract
Neurodevelopment involves the migration, projection, and integration of various cell types across different regions of the nervous system. Assembloids are self-organizing systems formed by the integration of multiple organoids or cell types. Here, we outline the generation and application of assembloids. We illustrate how assembloids recapitulate critical neurodevelopmental steps, like migration, axon projection, and circuit formation, and how they are starting to provide biological insights into neuropsychiatric disorders. Additionally, we review how assembloids can be used to study properties emerging from cell-cell interactions within non-neural tissues. Overall, assembloid platforms represent a powerful tool for discovering human biology and developing therapeutics.
논문정보
- Review Paper
- 2024년 10월 (BRIC 등록일 2024-10-28)
- 국외 연구진
- 생명과학 > 생명과학 기타
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