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한빛사논문
한빛사논문
- 조회214
Semin. Cancer Biol., Oct 19 2024, S1044-579X(24)00080-4 | https://doi.org/10.1016/j.semcancer.2024.10.002
Convergent evolution of senescent fibroblasts in fibrosis and cancer with aging
Jin Young Lee a, Tien Peng a,b
aDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy, and Sleep, San Francisco, CA, USA
bBakar Aging Research Institute, University of California San Francisco, San Francisco, CA, USA
Correspondence to: Tien Peng
Abstract
Aging is associated with stereotyped changes in the tissue microenvironment that increase susceptibility to diseases of the elderly, including organ fibrosis and cancer. From a tissue perspective, fibrosis and cancer can both be viewed as non-healing wounds with pathogenic activation of tissue repair pathways in the stroma. If fibrosis and cancer represent an example of the convergent evolution of maladaptive stromal responses in distinct pathologies, what are the analogous cell types that might emerge in both diseases that share similarities in identity and function? In this review, we explore how senescent fibroblasts form a nexus that connects the aging organ with both fibrosis and cancer. The advent of single cell sequencing, coupled with improved detection of cell types with senescent traits in vivo, have allowed us to identify senescent fibroblasts with similar identities in both fibrosis and cancer that share pro-fibrotic programs. In addition to their ability to reorganize the extracellular matrix in diseased states, these pro-fibrotic senescent fibroblasts can also promote epithelial reprogramming and immune rewiring, which drive disease progression in fibrosis and cancer. Finally, the identification of common pathogenic cell types in fibrosis and cancer also presents a therapeutic opportunity to target both diseases with a shared approach.
논문정보
- Review Paper
- 2024년 10월 (BRIC 등록일 2024-10-30)
- 국외 연구진
- 생명과학 > 노화/암생물학
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