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이혜리Hyeri Lee

경희대학교

Mol. Psychiatr., Oct 18 2024, | https://doi.org/10.1038/s41380-024-02792-2 Comorbid health outcomes in patients with schizophrenia: an umbrella review of systematic reviews and meta-analyses

Hyeri Lee^1,2,16, Jun Hyuk Lee³, Subin Lee⁴, Ji Soo Lim⁴, Hyeon Jin Kim^1,2,16, Jaeyu Park^1,2,16, Hayeon Lee¹, Guillaume Fond⁵, Laurent Boyer⁵, Lee Smith⁶, Masoud Rahmati^5,7,8, Mark A. Tully⁹, Damiano Pizzol^10,11, Hans Oh¹², Jiseung Kang^13,14,17 and Dong Keon Yon^1,2,4,15,17

¹Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.

²Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.

³Health and Human Science, University of Southern California, Los Angeles, CA, USA.

⁴Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.

⁵CEReSS-Health Service Research and Quality of Life Center, Assistance Publique-Hopitaux de Marseille, Aix Marseille University, Marseille, France.

⁶Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.

⁷Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.

⁸Department of Physical Education and Sport Sciences, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran.

⁹School of Medicine, Ulster University, Londonderry, Northern Ireland, UK.

¹⁰Health Unit, Eni, San Donato Milanese, Italy.

¹¹Health Unit Eni, Maputo, Mozambique.

¹²Suzanne Dworak Peck School of Social Work, University of Southern California, Los Angeles, CA, USA.

¹³Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.

¹⁴Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.

¹⁵Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.

¹⁶These authors contributed equally: Hyeri Lee, Hyeon Jin Kim, Jaeyu Park.

¹⁷These authors jointly supervised this work: Jiseung Kang, Dong Keon Yon.

Corresponding authors

Correspondence to Jiseung Kang or Dong Keon Yon.

Abstract

There is no comprehensive umbrella review exploring the connection between schizophrenia and various health outcomes. Therefore, we aimed to systematically review existing meta-analyses about schizophrenia-associated comorbid health outcomes and validate the evidence levels. We performed an umbrella review of meta-analyses of observational studies to explore comorbid health outcomes in individuals with schizophrenia. Searches were conducted across PubMed/MEDLINE, EMBASE, ClinicalKey, and Google Scholar up to September 5, 2023, targeting meta-analyses of observational studies related to comorbid health outcomes in individuals with schizophrenia. We applied AMSTAR2 for data extraction and quality assessment, adhering to PRISMA guidelines. Evidence credibility was evaluated and categorized by evidence quality. Our protocol was registered with PROSPERO (CRD42024498833). Risk and protective factors were analyzed and presented through equivalent odds ratios (eRR). In this umbrella review, we analyzed 9 meta-analyses, including 88 original articles, covering 21 comorbid health outcomes with over 66 million participants across 19 countries. Patients with schizophrenia showed significant associations with multiple health outcomes, including asthma (eRR, 1.71 [95% CI, 1.05-2.78], class and quality of evidence [CE] = non-significant), chronic obstructive pulmonary disease (1.73 [1.25-2.37], CE = weak), pneumonia (2.63 [1.11-6.23], CE = weak), breast cancer of female patients (1.31 [1.04-1.65], CE = weak), cardiovascular disease (1.53 [1.12-2.11], CE = weak), stroke (1.71 [1.30-2.25], CE = weak), congestive heart failure (1.81 [1.21-2.69], CE = weak), sexual dysfunction (2.30 [1.75-3.04], CE = weak), fracture (1.63 [1.10-2.40], CE = weak), dementia (2.29 [1.19-4.39], CE = weak), and psoriasis (1.83 [1.18-2.83] CE = weak). Our study underscores the imperative for an integrated treatment approach to schizophrenia, highlighting its broad impact across respiratory, cardiovascular, sexual, neurological, and dermatological health domains. Given the predominantly non-significant to weak evidence levels, further studies are needed to reinforce our understanding.

논문정보

형식Research article
게재일2024년 10월 (BRIC 등록일 2024-10-21)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

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