이정표 (서울대학교 의과대학, 서울특별시 보라매병원) | 한빛사논문 > 한빛사

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서울대학교 의과대학, 서울특별시 보라매병원

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Environ. Sci. Technol. , Oct 16 2024, | https://doi.org/10.1021/acs.est.4c03625 Exposure to Phthalates and Alternative Plasticizers in Patients with Impaired Kidney Function in Korea: Temporal Trend during 2011-2020 and Its Association with Chronic Kidney Disease

Gowoon Lee ¹, Jeonghwan Lee ², Na-Youn Park ³, Sunhey Jung ³, Inae Lee ⁴, Ba Reum Kwon ⁵, Ah-Reum Jo ⁴, Yaerim Kim ⁶, Hyunwoong Park ⁷, Younglim Kho ³, Jung Pyo Lee ^2,8, Kyungho Choi ⁴

¹Department of Safety Engineering, Korea National University of Transportation, Chungbuk 27469, Republic of Korea.

²Department of Internal Medicine, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Seoul 07061, Republic of Korea.

³Department of Health, Environmental and Safety, College of Bio Convergence, Eulji University, Seongnam-si, Gyeonggi-do 13135, Republic of Korea.

⁴Graduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea.

⁵Department of Environmental Science, Baylor University, Waco, Texas 76798, United States.

⁶Division of Nephrology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu 41931, Republic of Korea.

⁷Department of Laboratory Medicine, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Seoul 07061, Republic of Korea.

⁸Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Corresponding Authors: Jung Pyo Lee, Kyungho Choi

Abstract

Phthalates are chemical risk factors of chronic kidney disease (CKD); however, little is known about temporal trends of phthalate exposure and associated health risks among CKD patients. Such information is even scarce for alternative plasticizers. CKD patients were recruited from 2011 to 2020 in Korea ( n = 200) and assessed for the temporal changes of both traditional and alternative plasticizer exposure. Their associations with kidney dysfunction were also investigated. In CKD patients, urinary levels of DEP, BBzP, and DEHP metabolites declined significantly during this period, while those of the DEHTP metabolite increased. The level of DEHP metabolites showed a negative association with the estimated glomerular filtration rate (eGFR) in multiple association models, but additional eGFR subgroup analysis failed to show consistent results. Associations between phthalate exposure and eGFR were influenced by the severity of kidney dysfunction: DEHP and BBzP exposure showed negative associations with eGFR only among the patients with moderate kidney dysfunction (eGFR 30-59 mL/min/1.73 m²). Changing associations by CKD severity may be explained by negative correlations between eGFR and both urinary creatinine concentration and specific gravity. Our observations show that DEHTP has rapidly replaced DEHP and exposure to several phthalates adversely influences kidney function even among CKD patients.

논문정보

형식Research article
게재일2024년 10월 (BRIC 등록일 2024-10-21)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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