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J. Hazard. Mater., Oct 10 2024, 480 S0304-3894(24)02679-7 | https://doi.org/10.1016/j.jhazmat.2024.136100 Polystyrene microplastics induce activation and cell death of neutrophils through strong adherence and engulfment

Koung-Min Park ^a,b,1, Bora Kim^a,1, Wonjin Woo ^b,c, Lark Kyun Kim ^b,c, Young-Min Hyun ^a,b

^aDepartment of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea

^bBrain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea

^cDepartment of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea

¹K-M.P. and B.K. contributed equally to this study as co-first authors.

Corresponding author : Young-Min Hyun

Abstract

Ingested microplastics (MPs) can accumulate throughout whole body, which may induce the dysfunction of immune system. However, it remains unclear how MP exposure affects innate immune responses at the cellular level. We found that mouse neutrophils strongly bind and then engulf polystyrene MPs. This interaction leads to proinflammatory state of neutrophils and eventually results in apoptotic cell death through toll-like receptor signaling pathway in a bacteria-recognition mimetic manner. Moreover, our data verified that orally administered polystyrene MPs reach various organs in mice, where they are interacted with and endocytosed by neutrophils. We confirmed that human neutrophils also strongly bind and internalize polystyrene MPs. Additionally, RNA sequencing analysis of polystyrene MPs-exposed human neutrophils showed the upregulation of cell death-related function. Therefore, the accumulated MPs may exacerbate inflammatory immune response by disrupting neutrophil function. These results provide novel insight into the adverse responses of neutrophils induced by MP exposure.

논문정보

형식Research article
게재일2024년 10월 (BRIC 등록일 2024-10-16)
연구진국내 연구진
분야 생명과학 > 면역학

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