한빛사논문
Gongcheng Ma1, Qihang Ding2, Yue Wang3, Zhiwei Zhang3,4, Yuding Zhang3, Hui Shi5, Lintao Cai3,6, Ping Gong3, Pengfei Zhang3, Zhen Cheng5, Jong Seung Kim2
1School of Life Science and Technology, Xinxiang Medical University, Xinxiang, 453003 P. R. China
2Department of Chemistry, Korea University, Seoul, 02841 South Korea
3Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055 P. R. China
4University of Chinese Academy of Sciences, Beijing, 100049 P.R. China
5State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203 P. R. China
6Sino-Euro Center of Biomedicine and Health, Luohu, Shenzhen, 518024 P. R. China
G. M., Q. D., Y.W., and Z.Z. contributed equally to this work.
Corresponding Authors: Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim
Abstract
The therapeutic efficacy of photothermal therapy (PTT) under mild temperatures (<45 °C) is hindered as cancer cells can activate heat shock proteins (HSPs) to mend fever-type cellular damage swiftly. The previous attempt fabricated first-generation nanobombs (nanobomb1G) by self-assembly of polymeric NIR-II AIEgens and carbon monoxide (CO) carrier polymer mPEG(CO) to inhibit the expression of HSPs after intratumor injection. A new generation nanobomb (Stealth NanoBomb (SNB)) is developed by self-assembling small molecular NIR-II AIEgens with CO carrier polymer PLGA(CO) coated by PEG-lipid. This design allows for intravenous administration, enabling the SNB to circulate safely in the bloodstream and selectively target cancer cells. Upon accumulation in tumors, the SNB releases CO to effectively suppress HSP expression, enhancing the therapeutic efficacy of mild-temperature PTT. Compared to the previous generation, the SNB offers a safer, more stable, and more efficient CO gas/drug co-delivery system for cancer treatment. This work represents a significant advancement in PTT, providing a promising strategy for enhanced antitumor therapy with reduced systemic toxicity.
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