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한빛사논문
한빛사논문
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Crit. Care, Oct 04 2024, 28 (1) 326 | https://doi.org/10.1186/s13054-024-05101-z
A narrative review on antimicrobial dosing in adult critically ill patients on extracorporeal membrane oxygenation
Myeongji Kim1*, Maryam Mahmood1, Lynn L. Estes2, John W. Wilson1, Nathaniel J. Martin2, Joseph E. Marcus3,4, Ankit Mittal5, Casey R. O’Connell2 and Aditya Shah1
1Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, Rochester, MN, USA
2Department of Pharmacy, Mayo Clinic, Rochester, MN, USA
3Department of Medicine, Brooke Army Medical Center, Joint Base San Antonio-Fort Sam Houston, Fort Sam Houston, TX, USA
4Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
5Department of Infectious Diseases, AIG Hospitals, Hyderabad, India
*Correspondence: Myeongji Kim
Abstract
The optimal dosing strategy of antimicrobial agents in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) is unknown. We conducted comprehensive review of existing literature on effect of ECMO on pharmacokinetics and pharmacodynamics of antimicrobials, including antibacterials, antifungals, and antivirals that are commonly used in critically ill patients. We aim to provide practical guidance to clinicians on empiric dosing strategy for these patients. Finally, we discuss importance of therapeutic drug monitoring, limitations of current literature, and future research directions.
논문정보
- Review Paper
- 2024년 10월 (BRIC 등록일 2024-10-08)
- 국외 연구진
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