한빛사논문
Jea Sung Ryu 1, Soo Hyun Lee 2, Hyeran Kim 1, Hyunju Kang 1 3, Pei Li 1, Joo Hoon Lee 1, Hyowon Jang 1, Sunjoo Kim 4, Hyung-Jun Kwon 5, Ho Sang Jung 2, Yongwon Jung 3, Eun-Kyung Lim 1 6 7, Juyeon Jung 1 6 7 * Sung-Gyu Park 2 * and Taejoon Kang 1 7 *
1Bionanotechnology Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 34141, Republic of Korea
2Nano-BioConvergenceDepartment Korea Institute of Materials Science (KIMS) Changwon 51508, Republic of Korea
3Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141, Republic of Korea
4Department of Laboratory Medicine Gyeongsang National University Hospital Gyeongsang National University College of Medicine Jinju 52727, Republic of Korea
5Functional Biomaterial Research Center KRIBB Jeongeup 56212, Republic of Korea
6KRIBB School of Biotechnology University of Science and Technology (UST) Daejeon 34113, Republic of Korea
7School of Pharmacy Sungkyunkwan University (SKKU) Suwon 16419, Republic of Korea
*Corresponding authors: correspondence to Juyeon Jung, Sung-Gyu Park or Taejoon Kang
Abstract
A nanoplasmonic biosensor for the precise detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by leveraging advances in nanostructured sensing materials and highly selective monoclonal antibodies is presented. The sensor integrates plasmonic Au nanostructures optimized for surface-enhanced Raman scattering (SERS), enhancing sensitivity through unique light interactions at the nanoscale. Coupled with exclusive antibodies that specifically target SARS-CoV-2 and its evolving variants, this sensor demonstrates remarkable selectivity and versatility. Validated with 270 clinical samples, it demonstrates a sensitivity of 98.9% and specificity of 100%. More importantly, the virus in nasopharyngeal swab samples collected over 3 years, marking the long-term, large-scale clinical validation of the nanoplasmonic biosensor for SARS-CoV-2 is been successfully detected. Furthermore, the integration of this sensor with face masks enables the detection of airborne SARS-CoV-2, highlighting its potential for routine management of coronavirus disease 2019 (COVID-19).
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