정강훈 (Johns Hopkins School of Medicine, Allen Institute for Neural Dynamics) | 한빛사논문 > 한빛사

한빛사논문

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Johns Hopkins School of Medicine, Allen Institute for Neural Dynamics

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Nat. Neurosci., Sep 27 2024, | https://doi.org/10.1038/s41593-024-01770-9 Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation

Kanghoon Jung^1,2,3,4, Sarah Krüssel^1,2, Sooyeon Yoo¹, Myungmo An², Benjamin Burke¹, Nicholas Schappaugh^1,2, Youngjin Choi¹, Zirong Gu^5,6, Seth Blackshaw¹, Rui M. Costa^4,5 & Hyung-Bae Kwon^1,2

¹Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.

²Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.

³Allen Institute for Neural Dynamics, Seattle, WA, USA.

⁴Allen Institute, Seattle, WA, USA.

⁵Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.

⁶Present address: Department of Neuroscience, The University of Texas at Dallas, Richardson, Texas, USA.

Corresponding authors

Correspondence to Kanghoon Jung or Hyung-Bae Kwon.

Abstract

Spatial memories guide navigation efficiently toward desired destinations. However, the neuronal and circuit mechanisms underlying the encoding of goal locations and its translation into goal-directed navigation remain unclear. Here we demonstrate that mice rapidly form a spatial memory of a shelter during shelter experiences, guiding escape behavior toward the goal location-a shelter-when under threat. Dopaminergic neurons in the ventral tegmental area and their projection to the nucleus accumbens (NAc) encode safety signals associated with the shelter. Optogenetically induced phasic dopamine signals are sufficient to create a place memory that directs escape navigation. Converging dopaminergic and hippocampal glutamatergic inputs to the NAc mediate the formation of a goal-related memory within a subpopulation of NAc neurons during shelter experiences. Artificial co-activation of this goal-related NAc ensemble with neurons in the dorsal periaqueductal gray was sufficient to trigger memory-guided, rather than random, escape behavior. These findings provide causal evidence of cognitive circuit modules linking memory with goal-directed action.

논문정보

형식Research article
게재일2024년 09월 (BRIC 등록일 2024-10-04)
연구진국외 연구진
분야 바이오·의료융합 > 뇌인지과학

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