한빛사논문
- 조회185
Seong-Jin Kim1,6, Kang-Min Lee1,6, Si Hyung Park2, Taekyun Yang1, Ingyu Song1, Fumika Rai3, Ryo Hoshino3, Minsik Yun1, Chen Zhang1, Jae-Il Kim1, Sunjae Lee1, Greg S. B. Suh4, Ryusuke Niwa5, Zee-Yong Park1 &Young-Joon Kim1
1School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Republic of Korea.
2School of Horticulture and Forestry, College of Bio and Medical Sciences, Mokpo National University, Muan 58554, Republic of Korea.
3Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Ibaraki 305-8572, Japan.
4Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
5Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8577, Japan.
6These authors contributed equally: Seong-Jin Kim, Kang-Min Lee.
Corresponding author
Correspondence to Young-Joon Kim.
Abstract
Seminal fluid is rich in sugars, but their role beyond supporting sperm motility is unknown. In this study, we found Drosophila melanogaster males transfer a substantial amount of a phospho-galactoside to females during mating, but only half as much when undernourished. This seminal substance, which we named venerose, induces an increase in germline stem cells (GSCs) and promotes sperm storage in females, especially undernourished ones. Venerose enters the hemolymph and directly activates nutrient-sensing Dh44+ neurons in the brain. Food deprivation directs the nutrient-sensing neurons to secrete more of the neuropeptide Dh44 in response to infused venerose. The secreted Dh44 then enhances the local niche signal, stimulating GSC proliferation. It also extends the retention of ejaculate by females, resulting in greater venerose absorption and increased sperm storage. In this study, we uncovered the role of a sugar-like seminal substance produced by males that coordinates reproductive responses to nutritional challenges in females.
논문정보
- Research article
- 2024년 10월 (BRIC 등록일 2024-10-02)
- 국내(교신)+국외 연구진
- 생명과학 > 신경생물학
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