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Nat. Commun., Sep 27 2024, 15 (1) 8364 | https://doi.org/10.1038/s41467-024-52753-0
Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications
Wonmoon Song1,3, Changyub Lee2,3, Haein Jeong1, Seoyeon Kim2 & Nathaniel S. Hwang1,2
1Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Republic of Korea.
2School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, Republic of Korea.
3These authors contributed equally: Wonmoon Song, Changyub Lee.
Corresponding author
Correspondence to Nathaniel S. Hwang.
Abstract
Post-surgical adhesions frequently occur after intra-abdominal surgery, leading to severe complications. Despite the development of various types of adhesion barriers to address post-surgical adhesions, several limitations persist, including off-target localization, handling difficulties, and potential immunogenicity. Here, we report a spray-type adhesion barrier for broad, fast application, forming two sequential networks. The first network is formed by a polyelectrolyte complex of sulfated hyaluronic acid and chitosan, while the second network is established through pluronic® F127 thermogelation. This sprayable barrier served as both a physical protector for the damaged peritoneum and an immunomodulator for peritoneal macrophages, as evidenced its effectiveness in a rat ischemic button model. Taken together, this efficient adhesion barrier presents a promising solution for post-surgical adhesions.
논문정보
- Research article
- 2024년 09월 (BRIC 등록일 2024-09-30)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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