권바름 (서울대학교)

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서울대학교

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Environ. Int., Sep 23 2024, 192 S0160-4120(24)00616-0 | https://doi.org/10.1016/j.envint.2024.109030 Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links

Ba Reum Kwon ^a, Ah-Reum Jo ^a, Inae Lee^a, Gowoon Lee ^b, Young Joo Park ^c,d, Jung Pyo Lee^c,e, Na-Youn Park^f, Younglim Kho ^f, Sungkyoon Kim ^a, Kyunghee Ji ^g,h, Kyungho Choi^a

^aGraduate School of Public Health, Seoul National University, Seoul 08826, Republic of Korea

^bDepartment of Safety Engineering, Korea National University of Transportation, Chungju, Chungbuk 27469, Republic of Korea

^cDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

^dDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea

^eDepartment of Internal Medicine, Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea

^fDepartment of Health, Environment & Safety, Eulji University, Seongnam, Gyeonggi 13135, Republic of Korea

^gDepartment of Environmental Health, Yongin University, Yongin, Gyeonggi 17092, Republic of Korea

^hDepartment of Occupational and Environmental Health, Yongin University, Yongin, Gyeonggi 17092, Republic of Korea

Corresponding author : Kyungho Choi

Abstract

Organic UV filters (OUVFs) have been commonly used in sunscreen and many consumer products. Following dermal application, these compounds can enter circulation and may cause systemic effects in humans. In the present study, we chose four OUVFs frequently detected in the environment, i.e., avobenzone (AVB), benzophenone-3 (BP-3), octocrylene (OC), and octyl methoxycinnamate (OMC), and evaluated their thyroid, neurodevelopmental, and kidney toxicities. For this purpose, zebrafish embryos (<4 h post fertilization, hpf) were exposed to sublethal concentrations of AVB, BP-3, OC, or OMC until 120 hpf. Exposure to all OUVFs decreased thyroid hormone (TH) levels, probably by enhanced metabolism and excretion of THs (ugt1ab and/or sult1 st5) in the larval fish. Exposure to the OUVFs also induced hypoactivities and/or anxiety-like behaviors: Regulatory changes of mbp, gfap, c-fos, syn2a, sty1a, and stxbp1b genes, support the changes in normal neurobehavior of the larval fish. Moreover, the OUVFs exposure caused increased proteinuria in the fish, along with transcriptional changes of wt1, nephrin, podocin, and cdh17 genes, which could explain the observed reduction in kidney functions. Principal component analysis (PCA) implied the potential interplay of THs with neurogenesis, or podocyte differentiation of the larval fish. Toxicological consequences of altered TH homeostasis, neurobehavior, and kidney function at the early life stage warrant further investigations not only in humans but also in aquatic ecosystems.

논문정보

형식Research article
게재일2024년 09월 (BRIC 등록일 2024-09-30)
연구진국내 연구진
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