고규영 (KAIST, 기초과학연구원)

한빛사논문

조회180

KAIST, 기초과학연구원

CV File 258 kb

Nat. Neurosci., Sep 27 2024, | https://doi.org/10.1038/s41593-024-01701-8 Advances and controversies in meningeal biology

Christer Betsholtz^1,6, Britta Engelhardt ^2,6, Gou Young Koh^3,6, Donald M. McDonald ^4,6, Steven T. Proulx^2,6 & Julie Siegenthaler^5,6

¹Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden and Department of Medicine-Huddinge, Karolinska Institutet, Huddinge, Sweden.

²Theodor Kocher Institute, University of Bern, Bern, Switzerland.

³Center for Vascular Research, Institute for Basic Science and Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

⁴Department of Anatomy, Cardiovascular Research Institute, and UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.

⁵Department of Pediatrics, Section of Developmental Biology, University of Colorado, Anschutz Medical Campus Aurora, Colorado, CO, USA.

⁶These authors contributed equally: Christer Betsholtz, Britta Engelhardt, Gou Young Koh, Donald M. McDonald, Steven T. Proulx, Julie Siegenthaler.

Corresponding author

Correspondence to Julie Siegenthaler.

Abstract

The dura, arachnoid and pia mater, as the constituent layers of the meninges, along with cerebrospinal fluid in the subarachnoid space and ventricles, are essential protectors of the brain and spinal cord. Complemented by immune cells, blood vessels, lymphatic vessels and nerves, these connective tissue layers have held many secrets that have only recently begun to be revealed. Each meningeal layer is now known to have molecularly distinct types of fibroblasts. Cerebrospinal fluid clearance through peripheral lymphatics and lymph nodes is well documented, but its routes and flow dynamics are debated. Advances made in meningeal immune functions are also debated. This Review considers the cellular and molecular structure and function of the dura, arachnoid and pia mater in the context of conventional views, recent progress, and what is uncertain or unknown. The hallmarks of meningeal pathophysiology are identified toward developing a more complete understanding of the meninges in health and disease.

논문정보

형식Review Paper
게재일2024년 09월 (BRIC 등록일 2024-09-30)
연구진국내+국외 연구진
분야 의약학 > 재생의학

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