Kwangsik Nho ^1,2,3,4,41, Shannon L. Risacher ^1,3,41, Liana G. Apostolova ^1,3,5,6, Paula J. Bice ^1,3, Jared R. Brosch ^3,5, Rachael Deardorff ^3,5, Kelley Faber ^6,7, Martin R. Farlow ^3,5, Tatiana Foroud ^3,6,7, Sujuan Gao ^3,8, Thea Rosewood ^1,2,3, Jun Pyo Kim ^1,2,3, Kelly Nudelman ^3,6,7, Meichen Yu ^1,3, Paul Aisen ⁹, Reisa Sperling ¹⁰, Basavaraj Hooli ¹¹, Sergey Shcherbinin ¹¹, Diana Svaldi ¹¹, Clifford R. Jack Jr. ¹², William J. Jagust ¹³, Susan Landau ¹³, Aparna Vasanthakumar ¹⁴, Jeffrey F. Waring ¹⁴, Vincent Doré ^15,16, Simon M. Laws ¹⁷, Colin L. Masters ¹⁸, Tenielle Porter ¹⁷, Christopher C. Rowe ^16,18, Victor L. Villemagne ^16,19, Logan Dumitrescu ^20,21, Timothy J. Hohman ^20,21, Julia B. Libby ²⁰, Elizabeth Mormino ²², Rachel F. Buckley ¹⁰, Keith Johnson ^10,23, Hyun-Sik Yang ^10,24, Ronald C. Petersen ²⁵, Vijay K. Ramanan ²⁵, Nilüfer Ertekin-Taner ^26,27, Prashanthi Vemuri ¹², Ann D. Cohen ¹⁹, KangHsien Fan ²⁸, M. Ilyas Kamboh ²⁸, Oscar L. Lopez ^19,29, David A. Bennett ³⁰, Muhammad Ali ³¹, Tammie Benzinger ³², Carlos Cruchaga ^31,33, Diana Hobbs ³², Philip L. De Jager ³⁴, Masashi Fujita ³⁴, Vaishnavi Jadhav ^6,35, Bruce T. Lamb ^3,6,35, Andy P. Tsai ^22,35,36, Isabel Castanho ^37,38, Jonathan Mill ³⁷, Michael W. Weiner ^39,40, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)^*, the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI)^*, the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN)^*, the Australian Imaging, Biomarker & Lifestyle Study (AIBL)^*, Andrew J. Saykin ^1,2,3,5,6,**

¹Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
²Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, USA.
³Indiana Alzheimer’s Disease Research Center, Indiana University School of Medicine, Indianapolis, USA.
⁴Department of BioHealth Informatics, Indiana University, Indianapolis, USA.
⁵Department of Neurology,Indiana University School of Medicine, Indianapolis, USA.
⁶Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA.
⁷National Centralized Repository for Alzheimer’s Disease and Related Dementias, Indiana University School of Medicine, Indianapolis, USA.
⁸Department of Biostatistics, Indiana University School of Medicine, Indianapolis, USA.
⁹Department of Neurology, Keck School of Medicine, University of Southern California, San Diego, USA.
¹⁰Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
¹¹Eli Lilly and Company, Indianapolis, USA.
¹²Department of Radiology, Mayo Clinic, Rochester, USA.
¹³UC Berkeley Helen Wills Neuroscience Institute, University of California - Berkeley, Berkeley, USA.
¹⁴Genomics Research Center, AbbVie, North Chicago, USA.
¹⁵CSIRO Health and Biosecurity, Melbourne, Australia.
¹⁶Department of Molecular Imaging & Therapy, Austin Health, Heidelberg, Australia.
¹⁷Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Australia.
¹⁸Florey Institute of Neuroscience and Mental Health and The University of Melbourne, Parkville, Australia.
¹⁹Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA.
²⁰Vanderbilt Memory & Alzheimer’s Center, Vanderbilt University Medical Center, Nashville, USA.
²¹Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, USA.
²²Department of Neurology & Neurological Sciences, Stanford University, Stanford, USA.
²³Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
²⁴Center for Alzheimer’s Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA.
²⁵Department of Neurology, Mayo Clinic, Rochester, USA.
²⁶Department of Neurology, Mayo Clinic, Jacksonville, USA.
²⁷Department of Neuroscience, Mayo Clinic, Jacksonville, USA.
²⁸Department of Human Genetics, University of Pittsburgh, Pittsburgh, USA.
²⁹Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
³⁰Department of Neurological Sciences, Rush Medical College, Rush University, Chicago, USA.
³¹Department of Psychiatry, Washington University, St. Louis, USA.
³²Department of Radiology, Washington University School of Medicine, St. Louis, USA.
³³NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, USA.
³⁴Center for Translational and Computational Neuroimmunology, Department of Neurology and Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, USA.
³⁵Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, USA.
³⁶Wu Tsai Neurosciences Institute, Stanford University School of Medicine, Stanford, USA.
³⁷Department for Clinical and Biomedical Sciences, University of Exeter Medical School, University of Exeter, Exeter, UK.
³⁸Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
³⁹Departments of Radiology, Medicine, and Psychiatry, University of California-San Francisco, San Francisco, USA.
⁴⁰Department of Veterans Affairs Medical Center, San Francisco, USA.
⁴¹These authors contributed equally: Kwangsik Nho, Shannon L. Risacher.
^*Lists of authors and their affiliations appear at the end of the paper.

^**Corresponding author: correspondence to Andrew J. Saykin