한빛사논문
Indong Jun a,h, Haneul Choi b, Hyeok Kim c, Byoung Chan Choi d, Hye Jung Chang b, Youngjun Kim a, Sung Woo Cho e, James R. Edwards f, Suk-Won Hwang c,g,i, Yu-Chan Kim c, Hyung-Seop Han c, Hojeong Jeon c,g
aEnvironmental Safety Group, Korea Institute of Science & Technology Europe (KIST-EUROPE), Saarbrücken, 66123, Germany
bCenter for Hydrogen Energy Materials, Korea Institute of Science & Technology (KIST), Seoul, 02792, Republic of Korea
cBiomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea
dLaser Surface Texturing Group, AYECLUS, Gyeonggi-do, 14255, Republic of Korea
eDivision of Cardiology, Department of Internal Medicine, Inje University Ilsan Paik Hospital, College of Medicine, Inje University, Gyeonggi-do, 10380, Republic of Korea
fNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, OX3 7LD, United Kingdom
gKU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea
hDepartment of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea
iDepartment of Integrative Energy Engineering, Korea University, Seoul, 02841, Republic of Korea
Co-corresponding authors: Indong Jun, Hyung-Seop Han, Hojeong Jeon
Abstract
Medical stents are vital for treating vascular complications and restoring blood flow in millions of patients. Despite its widespread effectiveness, restenosis, driven by the complex interplay of cellular responses, remains a concern. This study investigated the reactions of vascular cells to nano/microscale wrinkle (nano-W and micro-W) patterns created on laser-textured nitinol (NiTi) surfaces using precisely tuned laser parameters. Evaluation of topographical effects on endothelial and smooth muscle cells (SMCs) revealed diverse morphologies, proliferation rates, and gene expressions. Notably, microscale wrinkle patterns exhibited reduced monocyte adhesion and inflammation-related gene expression, demonstrating their potential applications in mitigating vascular complications after stent insertion. In addition, this study introduces a comprehensive ex vivo metatarsal assay that shows enhanced angiogenesis on laser-textured NiTi surfaces. Laser-textured NiTi exhibits a guided formation process, emphasizing their potential to promote swift endothelialization. These findings underscore the efficacy of laser texturing for tailored cellular interactions on metallic surfaces and offer valuable insights into optimizing biocompatibility and controlling cellular responses, which may pave the way for innovative advances in vascular care and contribute to the ongoing improvement of stent insertion.
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