한빛사논문
Sungjun Lee1,2,11, Jeungeun Kum3,4,5,11, Sumin Kim2,3, Hyunjin Jung1,2, Soojung An1,2, Soon Jin Choi6, Jae Hyuk Choi3, Jinseok Kim4, Ki Jun Yu7, Wonhye Lee 4,8, Hyeok Kim6, Hyung-Seop Han6, Mikyung Shin2,3,9, Hyungmin Kim4,5 & Donghee Son1,2,10
1Department of Electrical and Computer Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea.
2Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea.
3Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon, Republic of Korea.
4Bionics Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
5Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul, Republic of Korea.
6Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
7School of Electrical and Electronic Engineering, Yonsei University, Seoul, Republic of Korea.
8Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
9Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea.
10Department of Artificial Intelligence System Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea.
11These authors contributed equally: Sungjun Lee, Jeungeun Kum.
Corresponding authors
Correspondence to Mikyung Shin, Hyungmin Kim or Donghee Son.
Abstract
drug-resistant epilepsy due to its spatial resolution and depth penetrability. However, current manual strategies, which use fixed neurostimulation protocols, cannot provide precise patient-specific treatment due to the absence of ultrasound wave-insensitive closed-loop neurostimulation devices. Here, we report a shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation. The sensor consists of a catechol-conjugated alginate hydrogel adhesive, a stretchable 16-channel electrode array and a viscoplastic self-healing polymeric substrate, and is coupled to a pulse-controlled transcranial focused ultrasound device. It can provide conformal and robust fixation to curvy cortical surfaces, and we show that it is capable of stable neural signal recording in awake seizure rodents during transcranial focused ultrasound neurostimulation. The sensing performance allows real-time detection of preseizure signals with unexpected and irregular high-frequency oscillations, and we demonstrate closed-loop seizure control supervised by intact cortical activity under ultrasound stimulation in awake rodents.
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